Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) Proteins (vps35)

vps35 belongs to a group of vacuolar protein sorting (VPS) genes. Additionally we are shipping vps35 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse vps35 vps35 65114 Q9EQH3
vps35 55737 Q96QK1
Rat vps35 vps35 25479  
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Top vps35 Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
$405.71
Details

vps35 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

Top referenced vps35 Proteins

  1. Human vps35 Protein expressed in Wheat germ - ABIN1325073 : Mao, Ladd, Gad, Rastetter, Johnson, Marzbani, Childs, Lu, Dang, Broussard, Stanton, Hanash, Disis: Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. in Journal of translational medicine 2014 (PubMed)

More Proteins for Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) Interaction Partners

Fruit Fly (Drosophila melanogaster) Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) interaction partners

  1. The in vivo effects of P316S, D620N and L774M of VPS35 using Drosophila as a model, were investigated.

  2. The findings of this study indicate that the VPS35 may play a crucial role in alpha-synucle in degradation by modulating the maturation of cathepsin D (show CTSD Proteins) and might thereby contribute to the pathogenesis of the disease.

  3. overexpression of Vps35 ameliorates the pathogenic mutant LRRK2 (show LRRK2 Proteins) eye phenotype in a Drosophila model of Parkinson's disease

  4. Vps35 negatively regulates actin (show ACTB Proteins) polymerisation, and genetic interactions suggest that some of the endocytic and signalling defects of vps35 mutants are due to this function

Mouse (Murine) Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) interaction partners

  1. Using in vivo knockdown of the critical retromer component VPS35, we demonstrate a specific role for this endosomal sorting complex in the trafficking of AMPA (show GRIA3 Proteins) receptors during NMDA-receptor-dependent LTP (show SCP2 Proteins) at mature hippocampal synapses.

  2. the data presented in this manuscript demonstrate a critical function of VPS35 in regulating PTH1R (show PTH1R Proteins) trafficking. This event and VPS35-interaction with PPP1R14C (show PPP1R14C Proteins) appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R (show PTH1R Proteins)-mediated catabolic response and bone remodeling.

  3. These results provide evidence for VPS35's function in promoting spine maturation, which is likely through increasing AMPA (show GRIA3 Proteins) receptor targeting to the postsynaptic membrane.

  4. Deletion of the VPS35 gene in dopamine (DA) neurons resulted in Parkinson disease-like deficits, including loss of DA neurons and accumulation of alpha-synuclein.

  5. These results suggest that VPS35 deficiency or mutation promotes Parkinson Disease (PD) pathogenesis, and reveals a crucial pathway, VPS35-Lamp2a-alpha-synuclein, to prevent PD pathogenesis.

  6. Our studies reveal unexpected genetic and functional interactions between VPS35 and EIF4G1, two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.

  7. Vps35 is necessary for mouse retinal ganglion cell survival and regeneration.

  8. VPS35 critically deregulates RANK signaling, thus restraining increased formation of hyperresorptive OCs and preventing osteoporotic deficits.

  9. VPS35 as an essential role in the suppression of AD neuropathology and in the inhibition of BACE1 (show BACE Proteins) activation and Abeta (show APP Proteins) production by promoting BACE1 (show BACE Proteins) endosome-to-Golgi retrieval.

  10. These results suggest that mouse Vps26b (show VPS26B Proteins)-Vps29 (show VPS29 Proteins)-Vps35 retromer complex is implicated in the transport of sortilin (show SORT1 Proteins) from endosomes to the trans-Golgi network.

Human Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) interaction partners

  1. The absence of mutations in VPS35 genes reveals that they are uncommon causes of Parkinson disease in Brazil

  2. VPS35 has been associated with autosomal dominant forms of Parkinson's disease with a high but incomplete penetrance .

  3. results lend further support to the notion that VPS35-DLP1 (show DNM1L Proteins) interaction is key to the retromer-dependent recycling of mitochondrial DLP1 (show DNM1L Proteins) complex during mitochondrial fission and provide a novel therapeutic target to control excessive fission and associated mitochondrial deficits.

  4. Silencing VPS35 increased N-Ras's association with cytoplasmic vesicles, diminished GTP (show AK3 Proteins) loading of Ras, and inhibited mitogen-activated protein kinase (show MAPK1 Proteins) signaling and growth of N-Ras (show NRAS Proteins)-dependent melanoma cells.

  5. deletion of VPS35 in yeast (vps35Delta) leads to a dose-dependent growth defect towards copper. This increased sensitivity could be rescued by transformation with yeast wild-type VPS35 but not by the expression of a construct harboring the yeast equivalent (i.e. D686N) of the most commonly identified VPS35-associated Parkinson disease mutation, p.D620N

  6. the Vps35 R524W-containing retromer has a decreased endosomal association, which can be partially rescued by R55, a small molecule previously shown to stabilize the retromer complex, supporting the potential for future targeting of the retromer complex in the treatment of Parkinson disease.

  7. X-ray crystallographic analysis of a 4-component complex comprising the VPS26 (show VPS26A Proteins) & VPS35 subunits of retromer, sorting nexin SNX3 (show SNX3 Proteins), & recycling signal from the divalent cation transporter DMT1 (show DMRT1 Proteins)-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 (show VPS26A Proteins) & SNX3 (show SNX3 Proteins); shows cooperative interactions among the VPS subunits, SNX3 (show SNX3 Proteins) & cargo that couple signal-recognition to membrane recruitment.

  8. findings provide evidence that the VPS35 D620N mutation likely confers pathogenicity through a partial loss of function mechanism and that this may be linked to other known pathogenic mechanisms such as mitochondrial dysfunction

  9. VPS35 mutations cause mitochondrial fragmentation and cell death in cultured neurons in vitro, in mouse substantia nigra neurons in vivo and in human fibroblasts from an individual with PD who has the VPS35(D620N) mutation.

  10. neither the R120W nor the N370S variant of the GBA (show GBA Proteins) gene nor D620N mutation of the VPS35 gene were detected among the Parkinson disease cases or the controls.

vps35 Protein Profile

Protein Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

Gene names and symbols associated with vps35

  • vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35)
  • vacuolar protein sorting-associated protein 35 (Tc00.1047053511367.170)
  • vacuolar protein sorting-associated protein 35 (Tb10.70.5460)
  • vacuolar protein sorting-associated protein 35 (BBOV_IV009740)
  • vacuolar protein sorting-associated protein 35 (CC1G_12185)
  • vacuolar protein sorting-associated protein 35 (PTRG_08682)
  • vacuolar protein sorting-associated protein 35 (CMU_017400)
  • vacuolar protein sorting-associated protein 35 (PHATR_43830)
  • vacuolar protein sorting-associated protein 35 (MCYG_00751)
  • vacuolar protein sorting-associated protein 35 (MGYG_01212)
  • vacuolar protein sorting-associated protein 35 (PGTG_10018)
  • vacuolar protein sorting-associated protein 35 (Tsp_09825)
  • vacuolar protein sorting 35 homolog (S. cerevisiae) (vps35)
  • Vacuolar protein sorting 35 (Vps35)
  • vacuolar protein sorting 35 (yeast) (vps35)
  • vacuolar protein sorting 35 (EHI_086580)
  • vacuolar protein sorting 35 (EHI_002990)
  • vacuolar protein sorting 35 (EHI_041950)
  • vacuolar protein sorting 35 (EHI_096520)
  • Vacuolar protein sorting 35 (Bm1_44045)
  • vacuolar protein sorting 35 (LOC100285267)
  • vacuolar protein sorting 35 (Vps35)
  • vacuolar protein sorting 35 homolog (S. cerevisiae) (Vps35)
  • 23.m05999 protein
  • AI647796 protein
  • bZ34G2.3 protein
  • CG5625 protein
  • DKFZp459E1510 protein
  • Dmel\\CG5625 protein
  • dvps35 protein
  • MEM3 protein
  • MGC81959 protein
  • PARK17 protein
  • si:rp71-34g2.3 protein
  • vps35 protein
  • wu:fa66e03 protein
  • wu:fb95c08 protein
  • zgc:136268 protein

Protein level used designations for vps35

vacuolar protein sorting-associated protein 35 , vacuolar protein sorting 35 homolog (S. cerevisiae) , vacuolar protein sorting 35 homolog , vacuolar protein sorting 35-like , CG5625-PA , CG5625-PB , Vps35-PA , Vps35-PB , vacuolar protein sorting 35 , Vacuolar protein sorting 35 , maternal embryonic message 3 , maternal-embryonic 3 , vesicle protein sorting 35 , hVPS35

GENE ID SPECIES
415750 Gallus gallus
465139 Pan troglodytes
475346 Canis lupus familiaris
717394 Macaca mulatta
3551850 Trypanosoma cruzi strain CL Brener
3663050 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5479130 Babesia bovis T2Bo
6004947 Coprinopsis cinerea okayama7130
6346969 Pyrenophora tritici-repentis Pt-1C-BFP
6995620 Cryptosporidium muris RN66
7203962 Phaeodactylum tricornutum CCAP 1055/1
9223543 Arthroderma otae CBS 113480
10032453 Arthroderma gypseum CBS 118893
10544762 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10907761 Trichinella spiralis
100015669 Monodelphis domestica
100056512 Equus caballus
100174173 Pongo abelii
100351202 Oryctolagus cuniculus
100367783 Saccoglossus kowalevskii
100551222 Meleagris gallopavo
100559729 Anolis carolinensis
100599794 Nomascus leucogenys
100623578 Sus scrofa
37536 Drosophila melanogaster
446307 Xenopus laevis
549980 Xenopus (Silurana) tropicalis
561697 Danio rerio
3405460 Entamoeba histolytica HM-1:IMSS
3407291 Entamoeba histolytica HM-1:IMSS
3410852 Entamoeba histolytica HM-1:IMSS
3411245 Entamoeba histolytica HM-1:IMSS
6103693 Brugia malayi
100285267 Zea mays
65114 Mus musculus
55737 Homo sapiens
25479 Rattus norvegicus
521864 Bos taurus
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