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VPS39 encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. Additionally we are shipping VPS39 Proteins (3) and many more products for this protein.
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Human Polyclonal VPS39 Primary Antibody for EIA, WB - ABIN783395
Nakamura, Hirata, Ohsumi, Wada: Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. in The Journal of biological chemistry 1997
Show all 3 references for ABIN783395
Human Polyclonal VPS39 Primary Antibody for WB - ABIN525102
Zeng, Carlin: Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells. in Journal of virology 2013
The present study provides the first phenotypic description of a lack of vam6 gene function in a multicellular organism.
our data indicate that TRAP1 (show TRAP1 Antibodies) and VPS39 are nonredundant and essentially required for early embryonic development
although only TBC1D15/Rab7-GAP (show TBC1D15 Antibodies) altered Rab7 (show RAB7A Antibodies)-GTP (show AK3 Antibodies) levels, both Rab7-GAP (show TBC1D15 Antibodies) and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
Antibodies to VAMP (show VAMP Antibodies) and SNAP inhibited sperm-zona pellucida interaction, suggesting their possible involvement in sperm membrane vesiculation.
TLP expression contributes to hypertrophic scar formation and contraction.
TLP (show TBPL1 Antibodies) likely acts as a molecular modulator capable of altering the balance of Smad3 (show SMAD3 Antibodies)- and Smad2 (show SMAD2 Antibodies)-dependent signaling through regulation of phosphorylation, thus facilitating collagen synthesis in fibroblasts.
Vps39 knockdown impairs late endosome fusion and fusion between late endosomes and lysosomes.
Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus
although only TBC1D15/Rab7-GAP (show TBC1D15 Antibodies) altered Rab7 (show RAB7B Antibodies)-GTP (show AK3 Antibodies) levels, both Rab7-GAP (show TBC1D15 Antibodies) and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
propose that TLP (show TBPL1 Antibodies) might regulate the balance of Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) signaling by localizing Smad4 (show SMAD4 Antibodies) intracellularly, thus contributing to cellular specificity of TGF-beta (show TGFB1 Antibodies) transcriptional responses in both normal and pathophysiology
This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.
, vacuolar protein sorting 39 homolog (S. cerevisiae)
, vesicle fusion protein
, vacuolar protein sorting 39
, TRAP1-like protein