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The protein encoded by VPS72 is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. Additionally we are shipping Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae) Antibodies (43) and Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae) Kits (1) and many more products for this protein.
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The study reports the crystal structure of the H2A.Z-binding domain of Drosophila melanogaster YL1 (dYL1-Z) in complex with an H2A.Z-H2B dimer at 1.9-A resolution.
The 2.7-A-resolution crystal structure of the human YL1-H2A.Z (show H2AFZ Proteins)-H2B complex shows that YL1 binding, similarly to ANP32E (show ANP32E Proteins) binding, triggers an extension of the H2A.Z (show H2AFZ Proteins) alphaC helix.
Results identify YL1 as a subunit of the TRRAP/TIP60 HAT complex, and also as a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP.
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
, vacuolar protein sorting-associated protein 72 homolog
, transcription factor-like 1
, potential vacuolar protein sorting protein
, vacuolar protein sorting 72 homolog (S. cerevisiae)
, protein YL-1
, transformation suppressor gene YL-1