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Valosin Containing Protein Proteins (vcp)

The protein encoded by vcp is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. Additionally we are shipping Valosin Containing Protein Antibodies (140) and Valosin Containing Protein Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
vcp 7415 P55072
vcp 269523 Q01853
Rat vcp vcp 116643 P46462
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Top Valosin Containing Protein Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 6 to 7 Days
$502.43
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

vcp Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Valosin Containing Protein (vcp) Interaction Partners

Human Valosin Containing Protein (vcp) interaction partners

  1. depletion of VCP enzymatic activity triggers cancer cell death in part through inadequate regulation of protein synthesis and amino acid metabolism.

  2. new role of VCP/p97 segregase in the timely processing of ubiquitinated CSB (show ERCC6 Proteins) from damaged chromatin.

  3. Ankrd13 proteins cooperate with VCP to regulate the lysosomal trafficking of ubiquitinated Cav-1 (show CAV1 Proteins).

  4. results suggest that human Cdc48 interacts functionally with the 20S proteasome (show PSMA5 Proteins).

  5. we show that loss of VCP induces endoplasmic reticulum stress and epithelial-mesenchymal transition

  6. interaction between SelK (show HSP Proteins) and p97(VCP) is SelS (show SELS Proteins)-dependent, and the resulting ERAD complex (SelS (show SELS Proteins)-p97(VCP)-SelK (show HSP Proteins)) plays an important role in ERAD and ER stress

  7. this study demonstrates significant correlation between the cytoplasmic expression of VCP and adverse prognosis in breast carcinoma, suggesting that VCP may serve as a prognostic biomarker in breast carcinoma.

  8. UBXD1 (show UBXN6 Proteins)-N intercalates into the p97 (show EIF4G2 Proteins)-ND1 (show MT-ND1 Proteins) interface, thereby modulating interdomain communication of p97 (show EIF4G2 Proteins) domains and its activity with relevance for disease pathogenesis

  9. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring.

  10. Data indicate that ATPase p97 (show EIF4G2 Proteins) is a key mediator of several protein homeostasis processes and is a strong potential cancer target.

Mouse (Murine) Valosin Containing Protein (vcp) interaction partners

  1. VCP (valosin-containing protein), together with its cofactor P47 (show MFGE8 Proteins) and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1 (show ATL1 Proteins)), regulates tubular ER formation

  2. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

  3. Global expression profiling of VCP(R155H/+) mice identified key dysregulated signaling pathways including genes involved in the physiological system development and function, diseases and disorders, and molecular and cellular functions.

  4. The results reveal an unexpected, crucial role of ATP consumption by VCP in determining cell fate in retinitis pigmentosa, and point to a promising new neuroprotective strategy for this currently incurable disease.

  5. Pro(178) and Pro(183) of SelS (show SELS Proteins) play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress

  6. Knockdown or chemical inhibition of p97 (show EIF4G2 Proteins) causes robust accumulation of USP33 (show USP33 Proteins) due to inhibition of its degradation

  7. conclude that the Akt (show AKT1 Proteins) substrate, VCP, mediates the increased expression of iNOS (show NOS2 Proteins) downstream from Hsp22 (show HSPB8 Proteins) through an NF-kappaB (show NFKB1 Proteins)-dependent mechanism

  8. Molecular dynamics simulations are used to probe energetic requirements of substrate protein translocation through the p97 (show EIF4G2 Proteins) pore and mechanisms of substrate binding and release from p97 (show EIF4G2 Proteins) subunits during the allosteric cycle.

  9. Data indicate that genetic ablation or chemical inhibition of p97 does not diminish DRiP antigen presentation nor does it alter the levels of MHC class I molecules on the cell surface.

  10. Cav-1 (show CAV1 Proteins) may be a cofactor in the interaction of Derlin-1 (show DERL1 Proteins) and N-glycosylated COX-2 and may facilitate Derlin-1 (show DERL1 Proteins)- and p97 (show EIF4G2 Proteins) complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.

Xenopus laevis Valosin Containing Protein (vcp) interaction partners

  1. p97 is an essential regulator of DNA damage-dependent CDT1 (show CDT1 Proteins) destruction

  2. CDC-48/p97 coordinates CDT-1 (show CDT1 Proteins) degradation with GINS chromatin dissociation to ensure faithful DNA replication

  3. data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation

Cow (Bovine) Valosin Containing Protein (vcp) interaction partners

  1. results suggest that VCP plays a mechanistic role in releasing WRNp from the nucleolus

Zebrafish Valosin Containing Protein (vcp) interaction partners

  1. When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration.

  2. CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells

Valosin Containing Protein (vcp) Protein Profile

Protein Summary

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

Gene names and symbols associated with vcp

  • valosin containing protein (VCP)
  • valosin containing protein (Bm1_56585)
  • valosin containing protein (LOC100136246)
  • valosin containing protein (Vcp)
  • valosin containing protein (vcp)
  • valosin-containing protein (Vcp)
  • 3110001E05 protein
  • ALS14 protein
  • CDC48 protein
  • IBMPFD protein
  • p93 protein
  • p97 protein
  • p97/VCP protein
  • TERA protein
  • wu:fd16d05 protein
  • wu:fj63d11 protein

Protein level used designations for vcp

transitional endoplasmic reticulum ATPase , valosin-containing protein , valosin containing protein , 15S Mg(2+)-ATPase p97 subunit , TER ATPase , yeast Cdc48p homolog , AAA ATPase p97 , Inv protein , homolog of yeast cdc48 , p97 ATPase

GENE ID SPECIES
427410 Gallus gallus
6106199 Brugia malayi
100136246 Oncorhynchus mykiss
7415 Homo sapiens
269523 Mus musculus
380491 Xenopus laevis
397524 Sus scrofa
481590 Canis lupus familiaris
507345 Bos taurus
327197 Danio rerio
116643 Rattus norvegicus
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