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The protein encoded by VANGL2 is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. Additionally we are shipping VANGL2 Proteins (4) and VANGL2 Kits (3) and many more products for this protein.
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Mouse (Murine) Polyclonal VANGL2 Primary Antibody for WB - ABIN1881989
Devenport, Fuchs: Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. in Nature cell biology 2008
Show all 5 references for ABIN1881989
Human Polyclonal VANGL2 Primary Antibody for ELISA, WB - ABIN190866
Kibar, Vogan, Groulx, Justice, Underhill, Gros: Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. in Nature genetics 2001
a new and essential role for Vangl2-dependent planar cell polarity signaling in the intraretinal path-finding of retinal ganglion cell axons
Vangl2-regulated polarisation and subsequent acquisition of an epithelial phenotype is essential to lengthen the tubular outflow vessel, a process that is essential for on-going cardiac morphogenesis (show XIRP1 Antibodies).
Vangl2 regulates E-cadherin (show CDH1 Antibodies) in epithelial cells.
Vangl2 function in podocytes is important for glomerular development and protects against glomerular injury in adult animals.
Vangl1 (show Vangl1 Antibodies) and Vangl2 may play a key role in the embryo implantation of mice
The first signal, controlled by cadherin, EGF (show EGF Antibodies)-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2 (show CELSR2 Antibodies), Celsr3 (show CELSR3 Antibodies), Frizzled3 (Fzd3 (show FZD3 Antibodies)) and Van Gogh like2 (Vangl2) organizes multicilia in individual cells (single-cell polarity)
Celsr2 (show CELSR2 Antibodies)-3 and Fzd3 (show FZD3 Antibodies) regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1 (show Vangl1 Antibodies)-2 that remain to be identified.
Testin (show TES Antibodies) interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.
Apical boundary rearrangement is inhibited in Vangl2 mutant neural epithelium.
Morphological and histological examination of homozygous mouse embryos revealed a neural tube closure defect that leads to craniorachischis ...Vangl2(m1Yzcm) may be a loss-of-function mutant.
dynamic Vangl2 intracellular distribution is coordinated with and necessary for the changes in convergence and extension cell behaviors during gastrulation
we found that the critical period for Vangl2 function coincides with the initial stages of FBM neuron migration out of rhombomere 4.
Vangl2 regulates FBM neuron migration by acting in floor plate cells, independently of cilia function
VANGL2 regulates the endocytosis and cell-surface availability of MMP14 in a manner that is dependent on focal adhesion kinase.
Vangl2(R259L) behaved like the wild-type allele in overexpression and morpholino knockdown/rescue assays in zebrafish embryos.
Rack1 (show GNB2L1 Antibodies) has a dominant-negative effect on Vangl2 localization and gastrulation.
data suggest that bbs8 (show TTC8 Antibodies) and vangl2 act synergistically on cell polarization to establish and maintain the appropriate length and number of cilia in the Kupffer's vesicle and thereby facilitate correct LR asymmetry
Vangl2 is required for asymmetric localization and posterior tilting of primary motile cilia at the apical membrane of epithelial cells.
show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain
The vangl2 gene product mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis.
VANGL2 is overexpressed in basal breast cancers. It is involved in the proliferative signal cascade of the VANGL2-SQSTM1 (show SQSTM1 Antibodies)-JNK (show MAPK8 Antibodies) pathway.
Propose that Arfrp1 (show ARFRP1 Antibodies) exposes a binding site on AP-1 (show FOSB Antibodies) that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell.
The aberrant VANGL2 promoter methylation and the decreased gene expression is associated with Tetralogy of Fallot.
Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT (show WNT2 Antibodies)/planar cell polarity pathway.
Van-Gogh-like 2 is frequently methylated in MSI (show MSI1 Antibodies)-CRCs with BRAF (show BRAF Antibodies) mutation and may act as a tumour suppressor gene, counteracting WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
these findings strongly implicate VANGL2 in the genetic causation of spinal NTDs in a subset of patients and provide additional evidence for a pathogenic role of PCP (show PRCP Antibodies) signaling in these malformations.
Loss of membrane targeting of Vangl1 (show Vangl1 Antibodies) and Vangl2 proteins causes neural tube defects.
The planar cell polarity genes Celsr1 (show CELSR1 Antibodies) and Vangl2 are required for normal lung branching morphogenesis.
Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase (show MMP20 Antibodies)-dependent invasion.
Results suggest that there is no specific mutation responsible for the Tetralogy of Fallot phenotype in the Vangl2 gene [Vangl2].
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.
vang-like 2 (van gogh, Drosophila)
, Van Gogh
, protein strabismus
, van Gogh-like protein 2
, vang-like protein 2
, vang-like 2
, loop tail associated protein
, loop-tail protein 1
, loop-tail-associated protein
, vang (van gogh)-like 2
, protein trilobite
, loop-tail protein 1 homolog
, strabismus 1