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Vcan is a member of the aggrecan/versican proteoglycan family. Additionally we are shipping Versican Kits (42) and Versican Proteins (5) and many more products for this protein.
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The isolation and characterization of a cDNA encoding zebrafish dermacan, a novel member of hyaluronan (HA)-binding proteoglycans, which was termed after its characteristic expression in the zebrafish dermal bones.
Versican localizes to the nucleus in proliferating mesenchymal cells and suggest role in mitotic spindle organization during cell division.
VCAN and VEGF (show VEGFA Antibodies) were associated with survival in CRC (show CALR Antibodies) patients with PM after CRS (show CARS Antibodies) and HIPEC
Versican is a novel modulator of hepatic fibrosis.
versican mRNA is up-regulated much more highly (>600 fold) by long term hypoxia (5 days) than by 1 day of hypoxia.
Versican V1 overexpression induces a myofibroblast-like phenotype in cultured fibroblasts.
Versican upregulation in Sezary cells alters growth, motility and resistance to chemotherapy.
Versican isoform V1 is associated with high-grade gliomas.
Significant elevation of VCAN and its associated molecules imply their role in multiple myeloma
Our results suggest that TGF-beta1 (show TGFB1 Antibodies) up-regulates versican expression by suppressing miR (show MLXIP Antibodies)-143, and this pathway is important for osteosarcoma cell migration and invasion.
Circulating monocytes may contribute to the fibrotic process in a subset of systemic sclerosis patients by amplifying a positive feedback loop consisting of versican, CCL2 (show CCL2 Antibodies), and the influx of monocytes
Pelvic irradiation increases versican expression in bladder and rectum.
The data suggest that versican plays an important role in fundamental, overlapping cellular processes in lung development and infection.
Our results show that versican released from glioma promotes tumor expansion through glioma-associated microglial/macrophage TLR2 (show TLR2 Antibodies) signaling and subsequent expression of MT1-MMP (show MMP14 Antibodies).
Arylsulfatase B (show ARSB Antibodies) regulates versican expression by galectin-3 (show LGALS3 Antibodies) and AP-1 (show JUN Antibodies) mediated transcriptional effects.
Versican regulates the growth of leiomyosarcoma tumors.
expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles
These findings suggest that versican and hyaluronan synthesis may play an important role in the innate immune response to gram-negative lung infection.
Versican 3'-untranslated region (3'UTR (show UTS2R Antibodies)) promotes dermal wound repair and fibroblast migration by regulating miRNA activity.
Data show that expression of mRNAs for aggrecan (show ACAN Antibodies), collagen type II, and versican were significantly effected by the intervention.
Data show that biglycan (show BGN Antibodies), collagen type I, collagen type II, decorin (show DCN Antibodies), and versican were significantly affected by vibration duration, frequency, and amplitude.
The relationship between hyaluronan synthesis and levels of versican, fibronectin (show FN1 Antibodies) and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene.
chondroitin sulfate proteoglycan 2a
, chondroitin sulfate proteoglycan 2b
, chondroitin sulfate proteoglycan 2 (versican)
, chondroitin sulfate proteoglycan 2
, versican core protein-like
, chondroitin sulfate proteoglycan core protein 2
, glial hyaluronate-binding protein
, large fibroblast proteoglycan
, versican core protein
, versican proteoglycan
, PG-M core protein
, Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M)
, heart defect