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Vesicle-Associated Membrane Protein, Associated Protein B and C Proteins (VAPB)

may play a role in exocytosis of neurotransmitters [RGD, Feb 2006].. Additionally we are shipping VAPB Kits (3) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat VAPB VAPB 60431 Q9Z269
Mouse VAPB VAPB 56491  
VAPB 326580 A2VDZ9
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Top VAPB Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
Yeast Wild boar His tag 1 mg Log in to see 56 to 66 Days
$2,539.17
Details
Yeast Cow His tag 1 mg Log in to see 56 to 66 Days
$2,539.17
Details

VAPB Proteins by Origin and Source

Origin Expressed in Conjugate
Cow (Bovine)

More Proteins for Vesicle-Associated Membrane Protein, Associated Protein B and C (VAPB) Interaction Partners

Mouse (Murine) Vesicle-Associated Membrane Protein, Associated Protein B and C (VAPB) interaction partners

  1. To identify pathological defects in animals expressing the P56S mutant VAPB protein at physiological levels in the appropriate tissues, we have generated Vapb knock-in mice

  2. The disruption of the IRE1 (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) pathway is a cause for the reduced myotube formation in P56S-VAPB-mutation expressing cells.

  3. Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels and FoxO (show FOXO3 Proteins) target gene transcriptional responses to fasting and refeeding

  4. Mice knocked-out for Vapb showed mild motor deficits after 18 months of age.

  5. VapB positively regulates RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis via PLCgamma2 (show PLCG2 Proteins)-Ca(2 (show CA2 Proteins)+)-NFAT (show NFATC1 Proteins) signaling

  6. Co-expression of mutant protein-associated protein B (show LEPREL2 Proteins) (VAPB) enhances the transactive response DNA-binding protein (show HSF4 Proteins)-43 (TDP-43 (show TARDBP Proteins))-induced motor neuronal cell death while that of wild type-VAPB attenuates it.

  7. Adeno (show ADORA2A Proteins)-associated viral-mediated over-expression of both wild-type and mutated form of human VAPB selectively induces death of primary motor neurons, albeit with different kinetics.

  8. However, VAPBP56S but not VAPBwt transgenic mice develop cytoplasmic TDP-43 (show TARDBP Proteins) accumulations within spinal cord motor neurons that were first detected at 18 months of age.

  9. The total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis.

VAPB Protein Profile

Protein Summary

may play a role in exocytosis of neurotransmitters

Gene names and symbols associated with VAPB

  • VAMP (vesicle-associated membrane protein)-associated protein B and C (Vapb)
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB)
  • vesicle-associated membrane protein, associated protein B and C (Vapb)
  • AI225786 protein
  • AI840687 protein
  • AI848259 protein
  • D2Abb2e protein
  • R75548 protein
  • Vamp33b protein
  • VAP33b protein

Protein level used designations for VAPB

VAMP-B , VAMP-associated protein B , VAP-B , vesicle-associated membrane protein, associated protein B and C , vesicle-associated membrane protein-associated protein B , VAMP-associated protein 33b

GENE ID SPECIES
60431 Rattus norvegicus
326580 Bos taurus
100144536 Sus scrofa
56491 Mus musculus
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