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Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) Proteins (VAMP2)

The protein encoded by VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Additionally we are shipping VAMP2 Antibodies (78) and VAMP2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse VAMP2 VAMP2 22318 P63044
VAMP2 24803 P63045
VAMP2 6844 P63027
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Top VAMP2 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,146.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,154.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,154.17
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,154.17
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$3,349.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

VAMP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
,

Top referenced VAMP2 Proteins

  1. Human VAMP2 Protein expressed in Escherichia coli (E. coli) - ABIN667044 : Hanson, Roth, Morisaki, Jahn, Heuser: Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. in Cell 1997 (PubMed)
    Show all 4 references for ABIN667044

More Proteins for Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) (VAMP2) Interaction Partners

Zebrafish Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) (VAMP2) interaction partners

  1. findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 Proteins) in mitochondrial function via its association with several mitochondrial proteins.

Mouse (Murine) Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) (VAMP2) interaction partners

  1. The balance between synaptophysin (show SYP Proteins) and sybII levels is critical for the correct targeting of sybII to synaptic vesicles and suggests that alterations in synaptophysin (show SYP Proteins) levels might affect the localisation of sybII and subsequent presynaptic performance.

  2. Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD (show TTN Proteins) greatly improves its function

  3. Vamp2 mutations impair the ability of Munc18-1 (show STXBP1 Proteins) to promote trans-SNARE (show VTI1B Proteins) zippering. These mutations inhibit spontaneous as well as evoked neurotransmitter release, providing evidence for the Vamp2-regulating function of Munc18-1 (show STXBP1 Proteins) in synaptic exocytosis.

  4. These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin (show INS Proteins) secretion.

  5. Results suggest that side chains in the syb2 transmembrane domain influence the kinetics of exocytosis by perturbing the packing of the surrounding lipids

  6. we demonstrate that Syb2 and SNAP25 (show SNAP25 Proteins) mediate the vesicular release of BDNF (show BDNF Proteins) in axons and dendrites of cortical neurons

  7. Here we report on transgenic mice expressing a ubiquitinated synaptic vesicle protein (Ub(G76V)-GFP-Syb2) that develop progressive degeneration of motor nerve terminals.

  8. VAMP2 is the major v-SNARE (show GOSR1 Proteins) involved in GLUT4 (show SLC2A4 Proteins) trafficking to the surface of 3T3-L1 adipocytes.

  9. These results indicate a role for the syb2 TMD in nascent fusion pores, but in a very different structural arrangement from that of the syntaxin transmembrane domains.

  10. Data show a significant increase of vesicle-associated membrane protein 2 (VAMP-2) mRNA expression, however, the expressions of synaptosome-associated protein of 25 kDa (SNAP-25 (show SNAP25 Proteins)) and syntaxin 1A (show STX1A Proteins) did not exhibit the changes in hippocampus.

Human Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) (VAMP2) interaction partners

  1. This study showed that decreased Levels of VAMP2 correlate with Duration of Dementia.

  2. VAMP2-NRG1 (show NRG1 Proteins) is a novel oncogenic fusion gene representing a new addition to the list of NRG1 (show NRG1 Proteins) fusion genes, which together may form an important diagnostic and clinical category of lung adenocarcinoma cases

  3. A large vesicular pool of VAMP2 maintained by AP180 is crucial to sustain efficient neurotransmission.

  4. SNARE (show NAPA Proteins) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.

  5. miR (show MLXIP Proteins)-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.

  6. The genetic variations of VAMP2, Synaptotagmin XI (show SYT11 Proteins) might be indication of the relationship between these genes and idiopathic generalized epilepsy

  7. BoNT/F5 cleaves substrate synaptobrevin-2 in a different location than the other BoNT/F subtypes, between (54)L and (55)E.

  8. unique mechanism of SNARE (show NAPA Proteins) motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 and CALM as cargo-specific adaptors for synaptobrevin 2 endocytosis

  9. VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival.

  10. SNAP-23 (show SNAP23 Proteins) and syntaxin-4 (show STX4 Proteins) are expressed in human eosinophils and are likely candidates for association with VAMP-2 during docking, which is followed by exocytosis

Cow (Bovine) Vesicle-Associated Membrane Protein 2 (Synaptobrevin 2) (VAMP2) interaction partners

  1. VAMP-2 is critical to lysosome fusion in membrane raft clustering, and this VAMP-2-mediated lysosome-MR signalosomes contribute to redox regulation of coronary endothelial function.

  2. VAMP2 is restricted from forming the SNARE (show NAPA Proteins) (soluble N-ethylmaleimide-sensitive fusion protein (show NSF Proteins) attachment protein receptor) complex in chromaffin granules from adrenal medullae to the same degree as in brain-purified synaptic vesicles.

  3. Lengthening juxtamembrane region of synaptobrevin-2 severely reduced occurrence of rapid single events, leaving slow ones unchanged. It also impaired increase in fast-fusion mode that normally follows elevation of intracellular Ca2 (show CA2 Proteins)+ levels.

VAMP2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.

Gene names and symbols associated with VAMP2

  • vesicle-associated membrane protein 2 (vamp2)
  • vesicle-associated membrane protein 2 (synaptobrevin 2) (VAMP2)
  • vesicle-associated membrane protein 2 (synaptobrevin 2) (vamp2-a)
  • vesicle-associated membrane protein 2 (synaptobrevin 2) (LOC100232098)
  • vesicle-associated membrane protein 2 (Vamp2)
  • vesicle-associated membrane protein 2 (synaptobrevin 2) (Vamp2)
  • vesicle-associated membrane protein 2 (synaptobrevin 2) (vamp2-b)
  • RATVAMPB protein
  • RATVAMPIR protein
  • SYB protein
  • Syb-2 protein
  • syb2 protein
  • sybII protein
  • VAMP-2 protein
  • vamp2 protein
  • vamp2-a protein
  • wu:fj61c06 protein
  • xsybi protein
  • xsybii protein
  • zgc:73302 protein

Protein level used designations for VAMP2

vesicle-associated membrane protein 2 (synaptobrevin 2) , VAMP-2 , synaptobrevin II , synaptobrevin-2 , vesicle-associated membrane 2 , Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2) , Vesicle-associated membrane protein (synaptobrevin 2) , synaptobrevin 2 , vesicle associated membrane protein 2 , vesicle-associated membrane protein 2 , SYBII

GENE ID SPECIES
336281 Danio rerio
747237 Pan troglodytes
394286 Xenopus laevis
100232098 Taeniopygia guttata
22318 Mus musculus
24803 Rattus norvegicus
6844 Homo sapiens
282116 Bos taurus
424827 Gallus gallus
479491 Canis lupus familiaris
100732271 Cavia porcellus
394287 Xenopus laevis
574134 Macaca mulatta
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