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Vinculin Proteins (VCL)

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Additionally we are shipping Vinculin Antibodies (187) and Vinculin Kits (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VCL 7414 P18206
VCL 22330 Q64727
Rat VCL VCL 305679 P85972
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Top Vinculin Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human GST tag Vinculin (VCL) (AA 2-235), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$217.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$310.00
Details

VCL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,
,

Top referenced Vinculin Proteins

  1. Mouse (Murine) Vinculin Protein expressed in Human Cells - ABIN2008297 : Strasser, Gimona, Herzog, Geiger, Small: Variable and constant regions in the C-terminus of vinculin and metavinculin. Cloning and expression of fragments in E. coli. in FEBS letters 1993 (PubMed)

More Proteins for Vinculin (VCL) Interaction Partners

Human Vinculin (VCL) interaction partners

  1. The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese

  2. Three novel genes were identified as recurrently mutated; MYCN (show MYCN Proteins), MYO5B and VCL, and mutations in these genes were exclusively found in malignant sympathetic paraganglioma tumors.

  3. roles and mechanisms of phospholipids in regulating the structure and function of vinculin and of its muscle-specific (show EIF3K Proteins) metavinculin splice variant.

  4. Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the vinculin tail helical bundle to mediate actin bundling.

  5. This study defined a plastic relationship between vinculin-mediated tension and adhesion complex area that controls fundamental cell-matrix adhesion properties.

  6. Analysis showed that ITGB4 (show ITGB4 Proteins) and VCL were upregulated in exosomes derived from taxane-resistant prostate cancer cells suggesting them as useful markers for progression of prostate cancer associated with taxane-resistance.

  7. vinculin, present in the joints of anti-citrullinated protein antibody (ACPA (show PRTN3 Proteins))(+) rheumatoid arthritis patients, was identified as an autoantigen targeted by ACPA (show PRTN3 Proteins) and CD4 (show CD4 Proteins)(+) T cells.

  8. The activation of vinculin by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin association.

  9. Data indicate that specific protein interactions are spatially segregated within focal adhesions (FAs (show FAS Proteins)) at the nanoscale to regulate vinculin activation and function.

  10. Vinculin expression was found to be significantly downregulated.

Mouse (Murine) Vinculin (VCL) interaction partners

  1. Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.

  2. These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.

  3. results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (show MMRN1 Proteins) remodeling in complex 3D environments by increasing cell-ECM (show MMRN1 Proteins) adhesion and traction force generation.

  4. Force-dependent conformational switch of alpha-catenin (show CTNNA1 Proteins) controls vinculin binding.

  5. Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.

  6. show that Src (show SRC Proteins) phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provide a detailed characterization of vinculin Y1065 mutations

  7. The E29R mutation might prime the vinculin head for F-actin binding, which results in higher cell stiffness, contractile force, and strengthening of focal adhesions.

  8. Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 (show TJP1 Proteins) and stabilization of CX43 (show GJA1 Proteins).

  9. serine phosphorylation is required for the activation of vinculin and force transmission in focal adhesions.

  10. VCL binding talin, but not Arp2 (show AICDA Proteins)/3, is critical for osteoclast function, and its selective inhibition retards physiological bone loss.

Pig (Porcine) Vinculin (VCL) interaction partners

  1. Results suggest that myosin VI (show MYO6 Proteins) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.

Vinculin (VCL) Protein Profile

Protein Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Gene names and symbols associated with Vinculin Proteins (VCL)

  • vinculin (VCL)
  • vinculin (vcl)
  • vinculin A (vinA)
  • Vinculin (Vinc)
  • vinculin (CpipJ_CPIJ013873)
  • vinculin (LOC100228062)
  • vinculin (LOC100356093)
  • vinculin (Vcl)
  • vinculin (Bm1_37935)
  • 9430097D22 protein
  • AA571387 protein
  • AI462105 protein
  • AW545629 protein
  • CG3299 protein
  • CMD1W protein
  • CMH15 protein
  • CT11081 protein
  • DDBDRAFT_0186762 protein
  • DDBDRAFT_0232320 protein
  • DDB_0186762 protein
  • DDB_0232320 protein
  • Dmel\\CG3299 protein
  • Dmvincp protein
  • EG:103B4.1 protein
  • hm:zehn2160 protein
  • im:6902790 protein
  • LOC100228062 protein
  • MV protein
  • MVCL protein
  • VCL protein
  • vcl-A protein
  • Vin protein
  • Vin2EF protein
  • vinc protein

Protein level used designations for Vinculin Proteins (VCL)

vinculin , CG3299-PA , Vinc-PA , vinculin at 2EF , vinculin-like , metavinculin , vinculin/metavinculin

GENE ID SPECIES
100064165 Equus caballus
450531 Pan troglodytes
552980 Danio rerio
8625369 Dictyostelium discoideum AX4
31201 Drosophila melanogaster
6047004 Culex quinquefasciatus
100036705 Xenopus (Silurana) tropicalis
100228062 Taeniopygia guttata
100410985 Callithrix jacchus
100476722 Ailuropoda melanoleuca
714312 Macaca mulatta
721921 Macaca mulatta
100075715 Ornithorhynchus anatinus
100583187 Nomascus leucogenys
7414 Homo sapiens
396422 Gallus gallus
100356093 Oryctolagus cuniculus
22330 Mus musculus
305679 Rattus norvegicus
783645 Bos taurus
373770 Xenopus laevis
100302597 Meleagris gallopavo
479252 Canis lupus familiaris
100357160 Oryctolagus cuniculus
396974 Sus scrofa
100722183 Cavia porcellus
101121312 Ovis aries
6102471 Brugia malayi
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