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Visual System Homeobox 2 Proteins (VSX2)

VSX2 encodes a homeobox protein originally described as a retina-specific transcription factor. Additionally we are shipping VSX2 Antibodies (61) and VSX2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VSX2 338917 P58304
VSX2 12677 Q61412
VSX2 171360  
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Top VSX2 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,036.00
Details
Yeast Oryzias latipes His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 11 to 13 Days
$418.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   50 μg Log in to see 11 to 13 Days
$440.00
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   50 μg Log in to see 11 to 13 Days
$462.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

VSX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)
Rat (Rattus)

More Proteins for Visual System Homeobox 2 (VSX2) Interaction Partners

Zebrafish Visual System Homeobox 2 (VSX2) interaction partners

  1. These data support a model by which vsx2, operating through the effector gene opo, acts as a central transcriptional node that coordinates neural retina patterning and optic cup invagination in zebrafish.

  2. Mutual antagonism of the paired-type homeobox (show PRRX1 Proteins) genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 (show CCND1 Proteins) expression.

  3. RET (show RET Proteins) expression is investigated within the brain of zebrafish; both RET (show RET Proteins) protein and mRNA are observed.

  4. In animals lacking Ret (show RET Proteins) or Gfra3 (show GFRA3 Proteins) function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.

  5. evaluation of noncoding sequences at the zebrafish ret (show RET Proteins) locus conserved among teleosts, and at the human RET (show RET Proteins) locus, conserved among mammals

  6. genes beyond RET (show RET Proteins) may be implicated in the genesis of sporadic cases of HD

  7. Vsx2-positive RPCs are fully multipotent retinal progenitors and that when Vsx2 is downregulated, Vsx2-negative progenitors escape Vsx2 repression and so are able to express factors that restrict lineage potential.

Human Visual System Homeobox 2 (VSX2) interaction partners

  1. The phenotype of this girl is unique and suggests a normal regulatory role for VSX2 in iris, zonule, and cone-rod development.

  2. The role of visual system homeobox 2 (VSX2), using human induced pluripotent stem cells derived from a patient with microphthalmia caused by an R200Q mutation in the VSX2 homeodomain region, is reported.

  3. Mutations in VSX2 represent an important cause of autosomal recessive microphthalmia in consanguineous pedigrees.

  4. study identified 3 recessive VSX2 mutations associated with isolated congenital anophthalmia or severe microphthalmia; also identified a novel inner retinal dystrophy (show MERTK Proteins) in 2 carrier parents suggesting a semidominant effect for this particular VSX2 mutation

  5. major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via PRC2 which therefore contributes to T-cell leukemogenesis.

  6. CHX10 regulates RdCVF (show NXNL1 Proteins) promoter activity in the inner retina.

  7. CHX10 and VSX1 (show VSX1 Proteins) may control retinal bipolar cell specification or differentiation by repressing genes required for the development of other cell types

  8. CHX10 may target specific motifs to inhibit rod photoreceptor gene expression in bipolar cells

  9. CHX10 defects in microphthalmia/anophthalmia patiients of midle-eastern origin are because od shared ancestry and consanguinity.

  10. These results support the role of SOX2 in ocular development. Loss of SOX2 function results in severe eye malformation. CHX10 was not implicated with microphthalmia/anophthalmia in our patient cohort.

Mouse (Murine) Visual System Homeobox 2 (VSX2) interaction partners

  1. Vsx2 represses Mitf (show MITF Proteins) in a cell-autonomous way. It also uses cell-nonautonomous mechanisms to regulate progenitor properties in the embryonic retina. Vsx2's role in regulating Mitf (show MITF Proteins) is in part separable from its role in promoting proliferation.

  2. The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.

  3. Our data suggest that the phenotypic severity of the CVC mutant depends on the weakened DNA binding activity elicited by the CVC mutation and a previously unknown protein interaction between Vsx2 and its regulatory target Mitf (show MITF Proteins).

  4. analysis of the regulatory role of a conserved motif adjacent to the homeodomain of Hox10 proteins

  5. Reducing GDF11 (show GDF11 Proteins) levels might promote restoration of retinal development in the microophthalmic Vsx2 mutant mouse.

  6. Data demonstrate that Hox10 genes play a critical role in the developing kidney.

  7. Blimp1 may play a role in photoreceptor development by repressing genes involved in bipolar cell fate specification and retinal cell proliferation in differentiating precursors; Blimp1 can bind to the Chx10 enhancer and repress Chx10 enhancer activity

  8. CHX10 regulates RdCVF (show NXNL1 Proteins) promoter activity in the inner retina.

  9. Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulator p27(Kip1 (show CDKN1B Proteins)).

  10. results have shown that the Hox10 and Hox11 (show TLX1 Proteins) paralogous genes are global regulators of the lumbosacral region of the axial skeleton and are integral in patterning principal limb elements

VSX2 Protein Profile

Protein Summary

This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities.

Gene names and symbols associated with VSX2

  • visual system homeobox 2 (VSX2)
  • visual system homeobox 2 (LOC100220947)
  • ret proto-oncogene receptor tyrosine kinase (ret)
  • visual system homeobox 2 (Vsx2)
  • visual system homeobox 2 (vsx2)
  • alx protein
  • c-ret protein
  • chx10 protein
  • cret protein
  • etID315074.13 protein
  • Hox-10 protein
  • Hox10 protein
  • MCOP2 protein
  • MCOPCB3 protein
  • or protein
  • RET1 protein
  • Vsx-2 protein
  • VSX2 protein
  • wu:fd13h01 protein

Protein level used designations for VSX2

visual system homeobox 2 , visual system homeobox 2-like , ceh-10 homeo domain containing homolog , ceh-10 homeodomain containing homolog , proto-oncogene tyrosine-protein kinase receptor Ret , receptor tyrosine kinase , ceh-10 homeodomain-containing homolog , homeobox protein CHX10 , C. elegans ceh-10 homeo domain containing homolog , ocular retardation , homeobox protein Chx10 , homeobox protein ALX , transcription factor VSX2

GENE ID SPECIES
528647 Bos taurus
699261 Macaca mulatta
741059 Pan troglodytes
100220947 Taeniopygia guttata
30512 Danio rerio
338917 Homo sapiens
490780 Canis lupus familiaris
12677 Mus musculus
171360 Rattus norvegicus
395536 Gallus gallus
796163 Danio rerio
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