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VDAC3 encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. Additionally we are shipping Voltage-Dependent Anion Channel 3 Antibodies (45) and and many more products for this protein.
This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls
The works available on VDAC cysteines support the notion that VDAC1 (show VDAC1 ELISA Kits), VDAC2 (show VDAC2 ELISA Kits), and VDAC3 proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)
VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space.
channel gating of VDAC3 might be controlled by redox sensing under physiological conditions
These data suggest that an interaction between Mcl-1 (show MCL1 ELISA Kits) and VDAC promotes lung cancer cell migration by a mechanism that involves Ca(2 (show CA2 ELISA Kits)+)-dependent reactive oxygen species production.
observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells
a VDAC3-Mps1 (show IDUA ELISA Kits) module at the centrosome promotes ciliary disassembly during cell cycle entry.
VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 (show IDUA ELISA Kits) to centrosomes.
VDAC 1 (show VDAC1 ELISA Kits), 2, and 3 recruit Parkin (show PARK2 ELISA Kits) to defective mitochondria to promote mitochondrial autophagy.
VDAC3 has a limited ability to support mitochondrial respiration and has no influence in the control of ROS (show ROS1 ELISA Kits) production.
VDAC2 (show VDAC2 ELISA Kits) and VDAC3 might have an alternative structural organization and different functions in outer dense fibers (show ODF1 ELISA Kits) than in mitochondria
Bcl-xL (show BCL2L1 ELISA Kits) interacts functionally with VDAC1 (show VDAC1 ELISA Kits) and -3 but not VDAC2 (show VDAC2 ELISA Kits).
(n VDAC3 deficient mice the defect is restricted to the heart and only to complex IV.
Vdacs are dispensable for both MPT and Bcl-2 (show BCL2 ELISA Kits) family member-driven cell death.
Bid (show BID ELISA Kits) catalyzes MAC formation in isolated mitochondria containing Bax (show BAX ELISA Kits) and/or Bak (show BAK1 ELISA Kits) with a time course of minutes and does not require VDAC1 (show VDAC1 ELISA Kits) or VDAC3.
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
, voltage-dependent anion channel 3
, voltage-dependent anion channel 5, pseudogene
, voltage-dependent anion-selective channel protein 3
, voltage-dependent anion channel 1 pseudogene 5
, outer mitochondrial membrane protein porin 3
, channel protein VDAC3
, mitochondrial outer membrane protein
, mitochondrial voltage dependent anion channel 3