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VHLL Proteins

(Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].

recommended

VHLL Protein (AA 1-139) (Strep Tag) (ABIN3075289)

Crystallography grade VHLL Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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recommended

VHLL Protein (AA 1-154) (His tag) (ABIN620853)

VHLL Origin: Human Recombinant > 95.0 % as determined by SDS-PAGE.

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recommended

VHLL Protein (ABIN1068513)

VHLL Origin: Human Recombinant

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VHLL Proteins by Grade

Find VHLL Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

VHLL Proteins by Origin

Find VHLL Proteins for a variety of species such as anti-Human VHLL. The species listed below are among those available. Click on a link to go to the corresponding products.

VHLL Proteins by Source

Here you will find VHLL Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

VHLL Proteins by Protein Type

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VHLL Proteins by Application

Find VHLL Proteins validated for a specific application such as ELISA, SDS, WB. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular VHLL Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

VHLL Protein (AA 1-139) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3075289

Quantity 1 mg

Datasheet Datasheet

VHLL Protein (AA 1-154) (His tag)

Reactivity Human

Source

Validations

Cat. No. ABIN620853

Quantity 50 μg

Datasheet Datasheet

VHLL Protein

Reactivity Human

Source

Validations

Cat. No. ABIN1068513

Quantity 50 μg

Datasheet Datasheet

Aliases for VHLL Proteins

VHL like (VHLL) Proteins
VHLP Proteins
VLP Proteins

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VHLL Proteins by Grade

VHLL Proteins by Origin

VHLL Proteins by Source

VHLL Proteins by Protein Type

VHLL Proteins by Application

Popular VHLL Proteins

Aliases for VHLL Proteins

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