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WAS Protein Family Homolog 1 Proteins (WASH1)

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity). Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse WASH1 WASH1 68767 Q8VDD8
WASH1 367328 B2RYF7
WASH1 100287171 A8K0Z3
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Top WAS Protein Family Homolog 1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,327.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,331.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,331.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,340.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,344.00
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,358.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

WASH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,

More Proteins for WAS Protein Family Homolog 1 (WASH1) Interaction Partners

Mouse (Murine) WAS Protein Family Homolog 1 (WASH1) interaction partners

  1. WASH deficiency impairs the association of RNF2 (show RNF2 Proteins) with AMBRA1 (show AMBRA1 Proteins) to impede AMBRA1 (show AMBRA1 Proteins) degradation.

  2. WASH complex regulates Arp2 (show AICDA Proteins)/3 complex and is required for cytokinesis and polar body extrusion.

  3. WASH is required for the differentiation commitment of hematopoietic stem cells by acting as an upstream regulator to modulate c-Myc (show MYC Proteins) transcription.

  4. WASH can suppress Beclin 1 (show BECN1 Proteins) ubiquitination to inactivate Vps34 (show PIK3C3 Proteins) activity leading to suppression of autophagy.

  5. WASH is a newly recognized regulator of T cell receptor, CD28 (show CD28 Proteins), LFA-1 (show ITGAL Proteins), and GLUT1 (show SLC2A1 Proteins) endosome-to-membrane recycling.

  6. WASH-mediated F-actin is requisite for the integrity of both endosomal and lysosomal networks in mammalian cells.

  7. WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells

  8. show that WASH generates an actin network on a restricted domain of sorting and recycling endosomes.

Human WAS Protein Family Homolog 1 (WASH1) interaction partners

  1. Stress-internalized EGFR co-segregates with exogenously expressed pre-melanosomal markers OA1 and fibrillar PMEL, following early endosomal sorting by the actin polymerization-promoting WASH complex

  2. FAM21 not only functions as an integral component of the cytoplasmic WASH complex, but also modulates NF-kappaB (show NFKB1 Proteins) gene transcription in the nucleus.

  3. The WASH-VPEF/FAM21-retromer complexe mediates endosome fission and sorting of virus-containing vesicles prior to virus core uncoating in the cytoplasm.

  4. The USP7 deubiquitinating enzyme is an integral component of the MAGE-L2-TRIM27 ligase and is essential for WASH-mediated endosomal actin assembly and protein recycling.

  5. WASH and the exocyst complex are required for matrix degradation by an exocytic mechanism that involves tubular connections between MT1-MMP (show MMP14 Proteins)-positive late endosomes and the plasma membrane in contact with the matrix.

  6. Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35 (show vps35 Proteins).

  7. WASH and Arp2 (show ACTR2 Proteins)/3 regulates integrin alpha5beta1-mediated invasive cell migration.

  8. Actin polymerization by WASH influences the shape and maturation of endosomes, and highlights a previously unrecognized role for WASH and the Arp2 (show ACTR2 Proteins)/3 complex in the degradative steps of endocytic trafficking.

  9. WASH exists in a multiprotein complex containing FAM21, which links WASH to endosomes and is required for WASH-dependent retromer-mediated sorting.

WAS Protein Family Homolog 1 (WASH1) Protein Profile

Protein Summary

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity).

Gene names and symbols associated with WASH1

  • WAS protein family homolog (Wash)
  • WAS protein family homolog (wash)
  • WAS protein family homolog 1 (WASH1)
  • WAS protein family homolog 1 (wash1)
  • 1110049F14Rik protein
  • FAM39B protein
  • FAM39E protein
  • ORF19 protein
  • si:ch211-11f8.1 protein
  • WASH protein
  • Wash1 protein
  • Wash2 protein
  • WASH2P protein

Protein level used designations for WASH1

WAS protein family homolog 1 , WAS protein family homolog 2 , CXYorf1-like protein on chromosome 9 , FLJ00075 protein , family with sequence similarity 39, member E , WAS protein family homolog 2 pseudogene , family with sequence similarity 39, member B

GENE ID SPECIES
68767 Mus musculus
367328 Rattus norvegicus
555174 Danio rerio
100287171 Homo sapiens
533602 Bos taurus
418145 Gallus gallus
495507 Xenopus laevis
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