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Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes (By similarity). Additionally we are shipping WHAMM Antibodies (2) and WHAMM Proteins (2) and many more products for this protein.
WHAMM directs the Arp2/3 complex to the endoplasmic reticulum for autophagosome biogenesis through an actin comet tail mechanism.
Data show that RhoD binds the actin nucleation-promoting factor WHAMM (WASp (show WASL ELISA Kits) homologue associated with actin Golgi membranes and microtubules), as well as the related filamin A (show FLNA ELISA Kits)-binding protein FILIP1 (show FILIP1 ELISA Kits).
results give rise to a model whereby distinct MT-bound and actin-nucleating populations of WHAMM collaborate during membrane tubulation
data suggest that WHAMM is required for peripheral spindle migration and asymmetric cytokinesis during mouse oocyte maturation
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes (By similarity). Involved as a regulator of Golgi positioning and morphology (By similarity). Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex.
WAS protein homology region 2 domain-containing protein 1
, WASP homolog-associated protein with actin, membranes and microtubules
, WH2 domain-containing protein 1
, WAS protein homology region 2 domain containing 1