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WDPCP encodes a cytoplasmic WD40 repeat protein. Additionally we are shipping WDPCP Antibodies (26) and many more products for this protein.
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These data suggest that, in addition to its role in controlling plasma membrane dynamics in collective mesenchymal cell movements, Wdpcp is also essential for normal cell cortex stability during epithelial homeostasis.
study identified control of septin localization by the planar cell polarity (PCP) protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in embryos
study linked mutations in Fritz (show FRZB Proteins) to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis
Wdpcp is required for Sept2 recruitment to actin filaments.
This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome.
Fritz PCP effector
, WD repeat-containing and planar cell polarity effector protein fritz homolog
, Bardet-Biedl syndrome 15 protein
, WD repeat-containing protein C2orf86
, WD repeat-containing protein C2orf86 homolog