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WDR26 encodes a member of the WD repeat protein family. Additionally we are shipping WDR26 Antibodies (29) and many more products for this protein.
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haploinsufficiency of WDR26 contributes to the pathology of 1q41q42 microdeletion syndrome.
It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A (show CORO1A Proteins)-like and Coro1A (show CORO1A Proteins)-dependent mechanism.
WDR26 affected beta-catenin (show CTNNB1 Proteins) levels. WDR26/Axin (show AXIN1 Proteins) binding is involved in the ubiquitination of beta-catenin (show CTNNB1 Proteins).
WDR26 serves as a scaffold that fosters assembly of a specific signaling complex consisting of Gbetagamma, PI3Kbeta and AKT2 (show AKT2 Proteins) in breast cancer.
The WDR26 gene was differentially methylated in monozygotic twins discordant for depressive disorder.
WDR26 functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes.
WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
these data suggest that MIP2 (show CXCL2 Proteins) may participate in the progression of cell proliferation in H9c2 cells.
WDR26 may act as a negative regulator in MAPK (show MAPK1 Proteins) signaling pathway and play an important role in cell signal transduction.
The results of this study indicated that WDR26 was up-regulated by oxidative stress and played a key role in H2O2-induced SH-SY5Y cell death, which may be mediated by the down-regulation of AP-1 (show FOSB Proteins) transcriptional activity.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene.
WD repeat domain 26
, WD repeat-containing protein 26
, WD repeat-containing protein 26-like
, CUL4- and DDB1-associated WDR protein 2
, GID complex subunit 7 homolog
, myocardial ischemic preconditioning up-regulated protein 2
, myocardial ischemic preconditioning upregulated protein 2