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WDR34 encodes a member of the WD repeat protein family. Additionally we are shipping WD Repeat Domain 34 Antibodies (32) and WD Repeat Domain 34 Proteins (3) and many more products for this protein.
In patients with short-rib polydactyly syndrome type III, primary cilia in WDR34 mutant fibroblasts were significantly shorter than normal and had a bulbous tip.
Mutations in WDR34 cause Jeune asphyxiating thoracic dystrophy. WDR34 is critical for ciliary functions essential to normal development and survival.
Results suggest that WDR34 is a TAK1 (show MAP3K7 ELISA Kits)-associated inhibitor of the IL-1R/TLR3 (show TLR3 ELISA Kits)/TLR4 (show TLR4 ELISA Kits)-induced NF-kappaB (show NFKB1 ELISA Kits) activation pathway.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
WD repeat-containing protein 34
, WD repeat domain 34
, WD repeat-containing protein 34-like