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WDR34 encodes a member of the WD repeat protein family. Additionally we are shipping WD Repeat Domain 34 Antibodies (32) and many more products for this protein.
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In patients with short-rib polydactyly syndrome type III, primary cilia in WDR34 mutant fibroblasts were significantly shorter than normal and had a bulbous tip.
Mutations in WDR34 cause Jeune asphyxiating thoracic dystrophy. WDR34 is critical for ciliary functions essential to normal development and survival.
Results suggest that WDR34 is a TAK1 (show MAP3K7 Proteins)-associated inhibitor of the IL-1R/TLR3 (show TLR3 Proteins)/TLR4 (show TLR4 Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation pathway.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
WD repeat-containing protein 34
, WD repeat domain 34
, WD repeat-containing protein 34-like