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WDR4 encodes a member of the WD repeat protein family. Additionally we are shipping WDR4 Antibodies (56) and many more products for this protein.
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WDR4 is an oncoprotein that negatively regulates PML (show PML Proteins) via ubiquitination to promote lung cancer progression by fostering an immunosuppressive and prometastatic tumor microenvironment
Combined autozygome/exome analysis revealed a novel missense mutation in WDR4 as the likely causal variant of Primordial dwarfism
regulates FEN1 (show FEN1 Proteins)'s potential DNA cleavage threat near the site of replication
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene.
TRM82 tRNA methyltransferase 82 homolog
, WD repeat-containing protein 4
, tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
, WD repeat domain 4 protein
, WD40 repeat protein 4