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Regulator of deubiquitinating complexes. Additionally we are shipping WDR48 Antibodies (25) and WDR48 Kits (2) and many more products for this protein.
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analysis of the function and regulation of the USP1 (show USP1 Proteins)-UAF1 complex
Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1 (show USP1 Proteins), USP12 (show USP12 Proteins) and USP46 (show USP46 Proteins).
our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival.
Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1
USP1 (show USP1 Proteins) and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 (show USP1 Proteins) nuclear localization signals.
p80 (show COIL Proteins) is recruited to the viral origin in an E1- and E2-dependent manner.
WDR20 (show WDR20 Proteins) serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 (show USP12 Proteins) complexes
These findings suggest that the interaction of human papillomavirus 11 and 31 E1 proteins with p80 (show COIL Proteins) is required for efficient maintenance of the viral episome in undifferentiated keratinocytes.
two novel multisubunit deubiquitinating enzyme complexes containing USP12 (show USP12 Proteins) and USP46 (show USP46 Proteins), respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2\; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes (By similarity).
USP1 associated factor 1
, USP1-associated factor 1
, WD repeat endosomal protein
, WD repeat-containing protein 48