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anti-WD Repeat Domain 77 (WDR77) Antibodies

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). Additionally we are shipping WD Repeat Domain 77 Proteins (8) and WD Repeat Domain 77 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WDR77 79084 Q9BQA1
WDR77 70465 Q99J09
WDR77 310769 Q4QR85
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Top anti-WD Repeat Domain 77 Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-WDR77 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate WB Suggested Anti-WDR77  Antibody Titration: 0.2-1 µg/mL  Positive Control:.93T cell lysate  WDR77 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB WDR77 monoclonal antibody (M01), clone 3F10 Western Blot analysis of WDR77 expression in HeLa on formalin-fixed paraffin-embedded human tonsil (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ICC, WB 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to WDR77 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml] WDR77 monoclonal antibody (M01), clone 3F10 Western Blot analysis of WDR77 expression in HeLa . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.05 mg Log in to see 2 to 3 Days
$618.75
Details
Human Rabbit Un-conjugated ELISA, WB   40 μg Log in to see 8 to 10 Days
$375.83
Details
Human Rabbit Un-conjugated WB Western Blot analysis of WDR77 expression in transfected 293T cell line by WDR77 MaxPab polyclonal antibody.Lane 1: WDR77 transfected lysate(36.70 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of WDR77 expression in transfected 293T cell line by WDR77 MaxPab polyclonal antibody.Lane 1: WDR77 transfected lysate(37.62 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to WDR77 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 9 Days
$430.00
Details

WDR77 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-WD Repeat Domain 77 Antibodies

  1. Human Monoclonal WDR77 Primary Antibody for WB - ABIN393715 : Peng, Chen, Melamed, Chiriboga, Wei, Kong, McLeod, Li, Li, Feng, Garabedian, Wang, Roeder, Lee: Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 5 references for ABIN393715

  2. Human Monoclonal WDR77 Primary Antibody for IHC (p), ELISA - ABIN566337 : Nicholas, Yang, Peters, Bill, Baiocchi, Yan, Sïf, Tae, Gaudio, Wu, Grever, Young, Lesinski: PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.). in PLoS ONE 2013 (PubMed)

More Antibodies against WD Repeat Domain 77 Interaction Partners

Xenopus laevis WD Repeat Domain 77 (WDR77) interaction partners

  1. Data indicate that MEP50 WD repeat protein (show DCAF7 Antibodies) is essential for methylation of histones H4 and H2A (show H2AFX Antibodies) by PRMT5 (show PRMT5 Antibodies) arginine methyltransferase.

  2. Structure of MEP50/Wdr77 in the PRMT5 (show PRMT5 Antibodies)-MEP50 complex

  3. Protein arginine methyltransferase Prmt5 (show PRMT5 Antibodies)-Mep50 methylates histones H2A (show H2AFX Antibodies) and H4 and the histone chaperone nucleoplasmin (show NPM1 Antibodies) in Xenopus laevis eggs

Human WD Repeat Domain 77 (WDR77) interaction partners

  1. MEP50 genes reduces gene expression through histone arginine methylation in keratinocytes.

  2. MEP50 can transform cells independent of AR and ER.

  3. Data indicate that MEP50 WD repeat protein (show DCAF7 Antibodies) is essential for methylation of histones H4 and H2A by PRMT5 (show PRMT5 Antibodies) arginine methyltransferase.

  4. These findings characterize PKG (show PRKG1 Antibodies) as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

  5. Data indicate a transcription complex androgen receptor (AR (show AR Antibodies))-p44 (show GTF2H2 Antibodies)-Smad1 (show GARS Antibodies), and confirmed for physical interaction by co-immunoprecipitaion.

  6. These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by WDR77's location in the cell.

  7. structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed beta-propeller MEP50 and the N-terminal domain of PRMT5 (show PRMT5 Antibodies), and delineates the structural elements of substrate recognition.

  8. p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis.

  9. expression and function of p44 in breast cancer; expression of p44 shows strong cytoplasmic expression in morphologically normal terminal ductal lobular units, while nuclear p44 is observed in both ductal carcinoma in situ and invasive carcinoma

  10. Here, we describe a novel component of the methylosome, a 50-kilodalton WD repeat protein (show DCAF7 Antibodies) termed methylosome protein 50 (MEP50).

Mouse (Murine) WD Repeat Domain 77 (WDR77) interaction partners

  1. These findings characterize PKG (show PRKG1 Antibodies) as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

  2. Silencing p21(Cip1 (show CDKN1A Antibodies)) or NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) expression with short hairpin RNA (shRNA) abolished astrocyte activation and rescued the astrocyte growth inhibition induced by deletion of the p44/WDR77 gene.

WD Repeat Domain 77 (WDR77) Antigen Profile

Protein Summary

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002

Gene names and symbols associated with WDR77

  • WD repeat domain 77 (wdr77) antibody
  • WD repeat domain 77 (WDR77) antibody
  • WD repeat domain 77 (LOC100352088) antibody
  • WD repeat domain 77 (LOC100357980) antibody
  • WD repeat domain 77 (Wdr77) antibody
  • 2610003I18Rik antibody
  • 2610312E17Rik antibody
  • C79984 antibody
  • MEP-50 antibody
  • MEP50 antibody
  • Nbla10071 antibody
  • p44 antibody
  • p44/MEP50 antibody
  • RGD1310479 antibody
  • RP11-552M11.3 antibody
  • valois antibody
  • WDR77 antibody

Protein level used designations for WDR77

WD repeat-containing protein 77 , methylosome protein 50 , WD repeat domain 77 , methylosome protein 50-like , androgen receptor cofactor p44 , MEP-50 , Ac2-269

GENE ID SPECIES
414664 Xenopus laevis
419865 Gallus gallus
677686 Macaca mulatta
100144971 Xenopus (Silurana) tropicalis
100352088 Oryctolagus cuniculus
100357980 Oryctolagus cuniculus
100391473 Callithrix jacchus
100614591 Pan troglodytes
79084 Homo sapiens
100172304 Pongo abelii
479902 Canis lupus familiaris
512993 Bos taurus
70465 Mus musculus
310769 Rattus norvegicus
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