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WD Repeat Domain 77 Proteins (WDR77)

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). Additionally we are shipping WD Repeat Domain 77 Antibodies (45) and WD Repeat Domain 77 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WDR77 79084 Q9BQA1
WDR77 70465 Q99J09
WDR77 310769 Q4QR85
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Top WD Repeat Domain 77 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

WDR77 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for WD Repeat Domain 77 (WDR77) Interaction Partners

Xenopus laevis WD Repeat Domain 77 (WDR77) interaction partners

  1. Data indicate that MEP50 WD repeat protein (show DCAF7 Proteins) is essential for methylation of histones H4 and H2A (show H2AFX Proteins) by PRMT5 (show PRMT5 Proteins) arginine methyltransferase.

  2. Structure of MEP50/Wdr77 in the PRMT5 (show PRMT5 Proteins)-MEP50 complex

  3. Protein arginine methyltransferase Prmt5 (show PRMT5 Proteins)-Mep50 methylates histones H2A (show H2AFX Proteins) and H4 and the histone chaperone nucleoplasmin (show NPM1 Proteins) in Xenopus laevis eggs

Human WD Repeat Domain 77 (WDR77) interaction partners

  1. MEP50 genes reduces gene expression through histone arginine methylation in keratinocytes.

  2. MEP50 can transform cells independent of AR and ER.

  3. Data indicate that MEP50 WD repeat protein (show DCAF7 Proteins) is essential for methylation of histones H4 and H2A by PRMT5 (show PRMT5 Proteins) arginine methyltransferase.

  4. These findings characterize PKG (show PRKG1 Proteins) as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

  5. Data indicate a transcription complex androgen receptor (AR (show AR Proteins))-p44 (show GTF2H2 Proteins)-Smad1 (show GARS Proteins), and confirmed for physical interaction by co-immunoprecipitaion.

  6. These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by WDR77's location in the cell.

  7. structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed beta-propeller MEP50 and the N-terminal domain of PRMT5 (show PRMT5 Proteins), and delineates the structural elements of substrate recognition.

  8. p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis.

  9. expression and function of p44 in breast cancer; expression of p44 shows strong cytoplasmic expression in morphologically normal terminal ductal lobular units, while nuclear p44 is observed in both ductal carcinoma in situ and invasive carcinoma

  10. Here, we describe a novel component of the methylosome, a 50-kilodalton WD repeat protein (show DCAF7 Proteins) termed methylosome protein 50 (MEP50).

Mouse (Murine) WD Repeat Domain 77 (WDR77) interaction partners

  1. These findings characterize PKG (show PRKG1 Proteins) as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

  2. Silencing p21(Cip1 (show CDKN1A Proteins)) or NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) expression with short hairpin RNA (shRNA) abolished astrocyte activation and rescued the astrocyte growth inhibition induced by deletion of the p44/WDR77 gene.

WD Repeat Domain 77 (WDR77) Protein Profile

Protein Summary

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002

Gene names and symbols associated with WD Repeat Domain 77 Proteins (WDR77)

  • WD repeat domain 77 (wdr77)
  • WD repeat domain 77 (WDR77)
  • WD repeat domain 77 (LOC100352088)
  • WD repeat domain 77 (LOC100357980)
  • WD repeat domain 77 (Wdr77)
  • 2610003I18Rik protein
  • 2610312E17Rik protein
  • C79984 protein
  • MEP-50 protein
  • MEP50 protein
  • Nbla10071 protein
  • p44 protein
  • p44/MEP50 protein
  • RGD1310479 protein
  • RP11-552M11.3 protein
  • valois protein
  • WDR77 protein

Protein level used designations for WD Repeat Domain 77 Proteins (WDR77)

WD repeat-containing protein 77 , methylosome protein 50 , WD repeat domain 77 , methylosome protein 50-like , androgen receptor cofactor p44 , MEP-50 , Ac2-269

GENE ID SPECIES
414664 Xenopus laevis
419865 Gallus gallus
677686 Macaca mulatta
100144971 Xenopus (Silurana) tropicalis
100352088 Oryctolagus cuniculus
100357980 Oryctolagus cuniculus
100391473 Callithrix jacchus
100614591 Pan troglodytes
79084 Homo sapiens
100172304 Pongo abelii
479902 Canis lupus familiaris
512993 Bos taurus
70465 Mus musculus
310769 Rattus norvegicus
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