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WD Repeat and FYVE Domain Containing 3 (WDFY3) ELISA Kits

WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. Additionally we are shipping WDFY3 Antibodies (30) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human WDFY3 WDFY3 23001 Q8IZQ1
Anti-Mouse WDFY3 WDFY3 72145 Q6VNB8
Anti-Rat WDFY3 WDFY3 305164  
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More ELISA Kits for WDFY3 Interaction Partners

Human WD Repeat and FYVE Domain Containing 3 (WDFY3) interaction partners

  1. we demonstrate that normally ALFY attenuates the canonical Wnt (show WNT2 ELISA Kits) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (show DVL3 ELISA Kits) and not of Dvl1 (show DVL1 ELISA Kits) or Dvl2 (show DVL2 ELISA Kits).

  2. ALFY binds selectively to LC3C and the GABARAPs through a LC3 (show MAP1LC3A ELISA Kits)-interacting region in its WD40 domain (show DCAF12L2 ELISA Kits).

  3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others

  4. Data suggest that p62 (show GTF2H1 ELISA Kits) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.

  5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.

  6. Alfy might target cytosolic protein aggregates for autophagic degradation.

Mouse (Murine) WD Repeat and FYVE Domain Containing 3 (WDFY3) interaction partners

  1. Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.

  2. Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.

  3. gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 and E16 (show SLC7A5 ELISA Kits) embryonic brain, but became diffuse after birth

WDFY3 Antigen Profile

Antigen Summary

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

Gene names and symbols associated with WDFY3

  • WD repeat and FYVE domain containing 3 (WDFY3) antibody
  • WD repeat and FYVE domain-containing protein 3 (MGYG_03998) antibody
  • WD repeat and FYVE domain containing 3 (Wdfy3) antibody
  • 2610509D04Rik antibody
  • ALFY antibody
  • AW319683 antibody
  • B930017C24 antibody
  • Bchs antibody
  • BWF1 antibody
  • D5Ertd66e antibody
  • Ggtb3 antibody
  • mKIAA0993 antibody
  • ZFYVE25 antibody

Protein level used designations for WDFY3

WD repeat and FYVE domain containing 3 , WD repeat and FYVE domain-containing protein 3 , autophagy-linked FYVE protein , beach domain, WD repeat and FYVE domain-containing protein 1 , galactosyltransferase 3 beta 1, 4

GENE ID SPECIES
100157904 Sus scrofa
461201 Pan troglodytes
10029110 Arthroderma gypseum CBS 118893
422613 Gallus gallus
23001 Homo sapiens
487841 Canis lupus familiaris
537096 Bos taurus
72145 Mus musculus
305164 Rattus norvegicus
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