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The protein encoded by WDHD1 contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. Additionally we are shipping WDHD1 Proteins (3) and many more products for this protein.
Showing 10 out of 34 products:
Xenopus laevis Monoclonal WDHD1 Primary Antibody for IHC (fro), IF - ABIN125939
Köhler, Schmidt-Zachmann, Franke: AND-1, a natural chimeric DNA-binding protein, combines an HMG-box with regulatory WD-repeats. in Journal of cell science 1997
Cow (Bovine) Polyclonal WDHD1 Primary Antibody for WB - ABIN2780828
Zhu, Ukomadu, Jha, Senga, Dhar, Wohlschlegel, Nutt, Kornbluth, Dutta: Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. in Genes & development 2007
Dna2 (show DNA2 Antibodies) co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 (show DNA2 Antibodies) interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Antibodies) and ATM (show ATM Antibodies).
RecQL4 (show RECQL4 Antibodies)-dependent association of Mcm10 (show MCM10 Antibodies) and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.
And-1 coordinates with Claspin (show CLSPN Antibodies) for efficient Chk1 (show CHEK1 Antibodies) activation in response to replication stress.
The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex.
And-1 together with HJURP (show HJURP Antibodies) regulates the assembly of new CENP-A (show CENPA Antibodies) onto centromeres.
Human And-1 facilitates loading of the MCM2-7 (show MCM2 Antibodies) helicase onto chromatin during the assembly of prereplicative complex.
Data show that And-1 forms a complex with both histone H3 and Gcn5.
Mcm10 (show MCM10 Antibodies) is required for chromatin loading of And-1.
Assembly of the Cdc45 (show CDC45 Antibodies)-Mcm2-7 (show MCM2 Antibodies)-GINS complex requires the Ctf4/And-1, RecQL4 (show RECQL4 Antibodies), and Mcm10 (show MCM10 Antibodies) proteins.
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms.
WD repeat and HMG-box DNA-binding protein 1
, WD repeat and HMG-box DNA binding protein 1
, WD repeat and HMG-box DNA-binding protein 1-like
, AND-1 protein
, acidic nucleoplasmic DNA-binding protein 1
, Acidic nucleoplasmic DNA-binding protein 1
, CTF4, chromosome transmission fidelity factor 4 homolog