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WSB1 encodes a member of the WD-protein subfamily. Additionally we are shipping WSB1 Antibodies (32) and many more products for this protein.
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WSB1 in glucose metabolism, and perhaps in mediating the Warburg effect in cancer cells by maintaining the function of HIF1.
Our findings show how WSB1 regulates key steps of the metastatic cascade in hypoxia-driven osteosarcoma
WSB1 up-regulates the expression of HIF-1alpha's target genes and promotes cancer invasion and metastasis through its effect on pVHL (show VHL Proteins)
combination of WSB1(3) silencing together with WSB1 isoforms 1+2 silencing in NB cells showed reduced growth, enhanced apoptosis rate, and increased sensitivity to chemotherapeutic agents, specifically related to low expression of WSB1
HIF1 (show HIF1A Proteins) has a role in regulating WSB-1 expression, which promotes hypoxia-induced chemoresistance in hepatocellular carcinoma cells
WSB-1 is part of an E3 ubiquitin ligase (show MUL1 Proteins) for the thyroid-hormone (show PTH Proteins)-activating type 2 iodothyronine deiodinase (show DIO2 Proteins) (D2).
WSB1 shows strong correlations between expression level and copy number, and also enhances the prognostic prediction when combined with other current prognostic factors in neuroblastoma (show ARHGEF16 Proteins).
the regulatory mechanisms by which HIPK2 (show HIPK2 Proteins) is maintained at a low level, by WSB-1 in cells under normal conditions, and stabilized by genotoxic stresses.
Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts
This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
SOCS box-containing WD protein SWiP-1
, WD repeat and SOCS box-containing 1
, WD repeat and SOCS box-containing protein 1
, WD-40-repeat-containing protein with a SOCS box 1