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WEE1 Homolog 2 (S. Pombe) Proteins (WEE2)

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Additionally we are shipping WEE1 Homolog 2 (S. Pombe) Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WEE2 494551 P0C1S8
Mouse WEE2 WEE2 381759 Q66JT0
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Top WEE1 Homolog 2 (S. Pombe) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

WEE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for WEE1 Homolog 2 (S. Pombe) (WEE2) Interaction Partners

Mouse (Murine) WEE1 Homolog 2 (S. Pombe) (WEE2) interaction partners

  1. WEE1B acts as a direct downstream substrate of protein kinase A (PKA) and that Ser (show SIGLEC1 Proteins) 15 of WEE1B is a potential PKA phosphorylation target in the G2/M transition of mouse embryos.

  2. findings demonstrate that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 (show CDK1 Proteins) by Wee1B

  3. Wee1B is a key maturation-promoting-factor inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest.

Pig (Porcine) WEE1 Homolog 2 (S. Pombe) (WEE2) interaction partners

  1. results suggest pWEE1B is activated after phosphorylation of the Ser77 residue, which is different from phosphorylation site that activates mWEE1B; that pWEE1B is localized in the nucleus; and that the nuclear localization is essential for its function

  2. insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs

  3. These results suggest that the inhibitory phosphorylation of CDC2 (show CDK1 Proteins), which is catalyzed by pigWee1B, but not pigMyt1, is involved in the meiotic arrest of porcine oocytes.

WEE1 Homolog 2 (S. Pombe) (WEE2) Protein Profile

Protein Summary

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.

Gene names and symbols associated with WEE2

  • WEE1 homolog 2 (S. pombe) (WEE2)
  • WEE1 homolog 2 (S. pombe) (Wee2)
  • WEE1 homolog 2 (S. pombe) (wee2)
  • Wee1B protein kinase (WEE1B)
  • Gm1065 protein
  • im:5913035 protein
  • si:ch211-238n5.5 protein
  • Wee1B protein
  • WEE2 protein
  • wu:fi13b10 protein
  • zgc:123074 protein

Protein level used designations for WEE2

wee1-like protein kinase 1B , wee1-like protein kinase 2 , wee1B kinase , mWee1B , Wee1-like protein kinase 1B , Wee1-like protein kinase 2 , Wee1B kinase

GENE ID SPECIES
494551 Homo sapiens
381759 Mus musculus
427918 Gallus gallus
475525 Canis lupus familiaris
327471 Danio rerio
100468598 Ailuropoda melanoleuca
100048934 Sus scrofa
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