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WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Additionally we are shipping WNK1 Proteins (6) and WNK1 Kits (5) and many more products for this protein.
Showing 10 out of 163 products:
Human Polyclonal WNK1 Primary Antibody for ICC, IF - ABIN153167
Wade, Fang, Liu, Li, Yang, Subramanya, Maouyo, Mason, Ellison, Welling: WNK1 kinase isoform switch regulates renal potassium excretion. in Proceedings of the National Academy of Sciences of the United States of America 2006
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HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).
wnk1 is a downstream target for Vegfr2 (vascular endothelial growth factor receptor-2 (show KDR Antibodies)) and Akt (show AKT1 Antibodies)/PI3K signaling and thereby affects angiogenesis in zebrafish embryos.
loss-of-function mutation in WNK1 induces an overexpression of KCC2 (show SLC12A5 Antibodies) and hinders proper peripheral sensory nerve development, a hallmark of HSANII
Akt3 (show AKT3 Antibodies) constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1 (show SGK1 Antibodies)/Cdc42 (show CDC42 Antibodies) pathway.
NKCC1 (show SLC12A2 Antibodies) and KCCs are coordinately regulated by L-WNK1 isoforms.
Single nucleotide polymorphisms STK39 (show STK39 Antibodies) and WNK were associated with hypertension and BP in our multicenter Belgian case-control study
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (show SLC12A5 Antibodies) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.
a novel gene, WNK1, for susceptibility to pelvic organ prolapse
findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (show NEDD4L Antibodies) substrate, thereby linking aldosterone and other NEDD4-2 (show NEDD4L Antibodies)-suppressing antinatriuretic hormones to NCC (show SLC12A3 Antibodies) phosphorylation status.
enhances BK channel (show KCNMA1 Antibodies) function by reducing ERK1/2 (show MAPK1/3 Antibodies) signaling-mediated lysosomal degradation of the channel
conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (show OXSR1 Antibodies) and SPAK (show STK39 Antibodies) in mediating proliferation, invasion, and gene expression in endothelial cells
The differential regulation of ROMK (show KCNJ1 Antibodies), large-conductance Ca(2 (show CA2 Antibodies)+)-activated K(+) (BK) channel (show KCNMA1 Antibodies), BK-alpha and NKCC2 (show SLC12A1 Antibodies) between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration
Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.
A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel (show KCNMA1 Antibodies) expression and K(+) secretion in collecting ducts.
increased protein expression levels of WNK1 and WNK4 (show WNK4 Antibodies) kinases cause PHAII by KLHL3 (show KLHL3 Antibodies) R528H mutation due to impaired KLHL3 (show KLHL3 Antibodies)-Cullin3-mediated ubiquitination.
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (show OSR1 Antibodies) and SPAK (show STK39 Antibodies) in mediating proliferation, invasion, and gene expression in endothelial cells
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.
WNK lysine deficient protein kinase 1
, serine/threonine-protein kinase WNK1-like
, WNK lysine deficient protein kinase 1 isoform
, erythrocyte 65 kDa protein
, prostate-derived sterile 20-like kinase
, protein kinase with no lysine 1
, serine/threonine-protein kinase WNK1
, protein kinase lysine-deficient 1