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WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Additionally we are shipping WNK1 Antibodies (165) and WNK1 Kits (4) and many more products for this protein.
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HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).
wnk1 is a downstream target for Vegfr2 (vascular endothelial growth factor receptor-2 (show KDR Proteins)) and Akt (show AKT1 Proteins)/PI3K signaling and thereby affects angiogenesis in zebrafish embryos.
loss-of-function mutation in WNK1 induces an overexpression of KCC2 (show SLC12A5 Proteins) and hinders proper peripheral sensory nerve development, a hallmark of HSANII
Single nucleotide polymorphisms STK39 (show STK39 Proteins) and WNK were associated with hypertension and BP in our multicenter Belgian case-control study
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 (show SLC12A5 Proteins) phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.
a novel gene, WNK1, for susceptibility to pelvic organ prolapse
findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 (show NEDD4L Proteins) substrate, thereby linking aldosterone and other NEDD4-2 (show NEDD4L Proteins)-suppressing antinatriuretic hormones to NCC (show SLC12A3 Proteins) phosphorylation status.
enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel
conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (show OXSR1 Proteins) and SPAK (show STK39 Proteins) in mediating proliferation, invasion, and gene expression in endothelial cells
Report generation of WNK1 knockout cell lines and effects on WNK signaling.
data suggest that WNK1 functions as a chloride sensor through direct binding of a regulatory chloride ion to the active site, which inhibits autophosphorylation
Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.
A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel (show KCNMA1 Proteins) expression and K(+) secretion in collecting ducts.
increased protein expression levels of WNK1 and WNK4 (show WNK4 Proteins) kinases cause PHAII by KLHL3 (show KLHL3 Proteins) R528H mutation due to impaired KLHL3 (show KLHL3 Proteins)-Cullin3-mediated ubiquitination.
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 (show OSR1 Proteins) and SPAK (show STK39 Proteins) in mediating proliferation, invasion, and gene expression in endothelial cells
WNK1 stimulates the activity of the Na-Cl cotransporter (show SLC12A3 Proteins) via SPAK (show STK39 Proteins), an effect antagonized by WNK4 (show WNK4 Proteins).
Results show that the expression profiles of Wnk1 isoforms change during the development, and that the expression of the Wnk1 splice variant containing the Hsn2 exon is prominent during developing and in adult mouse tissues.
subset of integral membrane proteins, therefore, requires an early dislocation event to expose part of their luminal domain to the cytosol, before HRD1 (show SYVN1 Proteins)-mediated polyubiquitination and dislocation
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.
WNK lysine deficient protein kinase 1
, serine/threonine-protein kinase WNK1-like
, WNK lysine deficient protein kinase 1 isoform
, erythrocyte 65 kDa protein
, prostate-derived sterile 20-like kinase
, protein kinase with no lysine 1
, serine/threonine-protein kinase WNK1
, protein kinase lysine-deficient 1