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WISP1 encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. Additionally we are shipping WISP1 Antibodies (92) and WISP1 Kits (37) and many more products for this protein.
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Human WISP1 Protein expressed in Escherichia coli (E. coli) - ABIN2667611
Davies, Davies, Sanders, Parr, Torkington, Jiang: Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. in International journal of oncology 2010
Show all 8 references for ABIN2667611
Human WISP1 Protein expressed in Human Cells - ABIN2002857
Pennica, Swanson, Welsh, Roy, Lawrence, Lee, Brush, Taneyhill, Deuel, Lew, Watanabe, Cohen, Melhem, Finley, Quirke, Goddard, Hillan, Gurney, Botstein, Levine: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 5 references for ABIN2002857
Two paralogs of mammalian wisp1 genes were found in zebrafish.
WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut (show GUSB Proteins).
Data show that WNT1-inducible signaling pathway protein-1 (WISP)-1/CCN4 expression was correlated with vascular endothelial growth factor-C (VEGF-C (show VEGFC Proteins)) expression in Oral squamous cell carcinoma (OSCC) specimens.
WISP1-induced IL-6 (show IL6 Proteins) expression contributes to the pro-proliferative effect on fibroblasts.
WISP1 plays an important role in regulating proliferation and apoptosis of Jurkat cells.
Study showed that DNA methylation (show HELLS Proteins) of the WISP1 promoter in the majority of the oral squamous cell carcinoma explains its expression regulation.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3 (show TGFB3 Proteins).
Studies indicate that the CYR61 (show CYR61 Proteins) CTGF (show CTGF Proteins) NOV (show NOV Proteins) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Proteins), CCN2 (show CTGF Proteins), CCN3 (show NOV Proteins), CCN4, CCN5 (show WISP2 Proteins) and CCN6 (show WISP3 Proteins) and have been identified in various types of cancer.
Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors. [review]
WISP1 contributed to radioresistance primarily by repressing irradiation-induced DNA damage and activating PI3K (show PIK3CA Proteins) kinase.
WISP1 functions as an oncogene (show RAB1A Proteins) for human breast cancer. Ectopic expression of WISP1 in breast cancer cells promotes cell growth and metastasis.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4 (show TLR4 Proteins)/TRIF (show RNF138 Proteins) signaling.
the Bmp3 (show BMP3 Proteins)/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
WISP1 is a novel regulator of bone turnover and Wnt (show WNT2 Proteins) signaling
The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin (show INS Proteins) resistance and could be a novel therapeutic target for obesity.
Wnt5a (show WNT5A Proteins)-induced Wnt1 (show WNT1 Proteins)-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress.
Notch1 (show NOTCH1 Proteins)-induced WISP-1 expression appeared to be Wnt11 (show WNT11 Proteins)-dependent, but Wnt1 (show WNT1 Proteins)-independent
WISP-1 exerts paracrine action on immune cells by inhibiting their response to IL12 (show IL12A Proteins)
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
WNT1 inducible signaling pathway protein 1
, CCN family member 4
, WNT1 induced secreted protein 1
, WNT1-inducible-signaling pathway protein 1
, Wnt-1 inducible signaling pathway protein 1
, Wnt-1-induced secreted protein