anti-WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Antibodies

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Additionally we are shipping WWP1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WWP1 11059 Q9H0M0
WWP1 107568 Q8BZZ3
WWP1 297930  
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Top anti-WWP1 Antibodies at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-WWP1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to WWP1 on A-431 cell (antibody concentration 10 µg/mL). WWP1 monoclonal antibody (M01), clone 1A7 Western Blot analysis of WWP1 expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of WWP1 expression in transfected 293T cell line by WWP1 monoclonal antibody (M01A), clone 1A7.<br><br>Lane 1: WWP1 transfected lysate(105.2 KDa).<br>Lane 2: Non-transfected lysate.<br> Western Blot detection against Immunogen (37.73 KDa) . 200 μL Log in to see 11 to 12 Days
$430.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to WWP1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to WWP1 on A-431 cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Mouse Un-conjugated IF, ELISA, WB 100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Rabbit Un-conjugated WB WWP1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details
Human Rabbit Un-conjugated IF (p), IHC (p)   100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.1 KDa) . 50 μL Log in to see 11 to 12 Days
$298.57
Details
Human Rabbit Un-conjugated WB Western Blot analysis of WWP1 expression in transfected 293T cell line by WWP1 MaxPab polyclonal antibody.<br><br>Lane 1: WWP1 transfected lysate(105.20 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Log in to see 11 to 12 Days
$418.57
Details

WWP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , ,
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Mouse (Murine) ,


Rat (Rattus) ,


Top referenced anti-WWP1 Antibodies

  1. Human Monoclonal WWP1 Primary Antibody for IF, IHC (p) - ABIN564794 : Edwards, Clowes, Tsang, Connell, Sanderson, Luzio, Reid: Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. in The Biochemical journal 2009 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal WWP1 Primary Antibody for ELISA, WB - ABIN524447 : Subik, Shu, Wu, Liang, Hicks, Boyce, Schiffhauer, Chen, Chen, Tang, Xing: The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. in Bone 2012 (PubMed)

More Antibodies against WWP1 Interaction Partners

Human WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) interaction partners

  1. study describes a physical and functional interaction between Ebola virus VP40 (eVP40) and WWP1, a host E3 ubiquitin ligase (show MUL1 Antibodies) that ubiquitinates VP40 and regulates virus-like particles egress.

  2. Knock-down of WWP1 abrogates DNA damage-induced down-regulation of DeltaNp63alphaand partially rescues cell apoptosis

  3. Describe an autoinhibitory mechanism for WWP1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.

  4. results demonstrate that WWP1 catalyzes the formation of Ub chains through a sequential addition mechanism, in which Ub monomers are transferred in a successive fashion to the substrate, and that ubiquitination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HECT domain.

  5. Study shows that WWP1 was upregulated in prostate cancer (PCa (show FLVCR1 Antibodies)) clinical specimens and contributed to cancer cell invasion, indicating that this target of Mir (show MLXIP Antibodies)-452 functioned as an oncogene (show RAB1A Antibodies).

  6. Overexpression of WWP1 promotes tumorigenesis in patients with hepatocellular carcinoma.

  7. PTPN14 (show PTPN14 Antibodies), a Pez (show PTPN14 Antibodies) mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.

  8. miR (show MLXIP Antibodies)-21 overexpression or WWP1 knockdown in endothelial progenitor cells significantly activates the TGFbeta (show TGFB1 Antibodies) signaling pathway and inhibits cell proliferation.

  9. The cancer-driven alteration of WWP1 culminates in excessive TbetaRI (show TGFBR1 Antibodies) degradation and attenuated TGFbeta1 (show TGFB1 Antibodies) cytostatic signaling, a consequence that could conceivably confer tumorigenic properties to WWP1.

  10. Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 (show SMURF1 Antibodies) and Smurf2 (show SMURF2 Antibodies) genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.

Mouse (Murine) WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) interaction partners

  1. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin (show HTT Antibodies). This suggests that the E3 ligase WWP1 is involved in the pathogenesis of Huntington's disease; therefore, it may be a novel target for therapeutic intervention.

  2. Cardiomyocyte-specific overexpression of Wwp1 contributes to reduction in Connexin 43 (show GJA1 Antibodies) and arrhythmogenesis.

  3. Wwp1 negatively regulates osteoblast functions.

  4. WWP1 functions as an E3 ligase when cells are stimulated with LPS (show TLR4 Antibodies) by binding to TRAF6 (show TRAF6 Antibodies) and promoting K48-linked polyubiquitination. This results in the proteasomal degradation of TRAF6 (show TRAF6 Antibodies)

  5. WWP1 down-regulates AMPKalpha2 under high glucose culture conditions via the ubiquitin-proteasome pathway

  6. Wwp1 promotes ubiquitination and degradation of JunB (show JUNB Antibodies), an AP-1 (show JUN Antibodies) transcription factor that positively regulates osteoblast differentiation.

WWP1 Antigen Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene names and symbols associated with WWP1

  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1) antibody
  • WW domain containing E3 ubiquitin protein ligase 1 (WWP1) antibody
  • WW domain containing E3 ubiquitin protein ligase 1 (wwp1) antibody
  • WW domain containing E3 ubiquitin protein ligase 1 (Wwp1) antibody
  • 8030445B08Rik antibody
  • AIP5 antibody
  • hSDRP1 antibody
  • SDRP1 antibody
  • Tiul1 antibody
  • wu:fb30b12 antibody
  • WWP1 antibody
  • zgc:66401 antibody

Protein level used designations for WWP1

E3 ubiquitin ligase SMURF1 , E3 ubiquitin-protein ligase SMURF1 , WW domain containing E3 ubiquitin protein ligase 1 , smad ubiquitination regulatory factor 1 , WW domain-containing protein 1 , NEDD4-like E3 ubiquitin-protein ligase WWP1 , Nedd-4-like ubiquitin-protein ligase , TGIF-interacting ubiquitin ligase 1 , atrophin-1 interacting protein 5 , atrophin-1-interacting protein 5

GENE ID SPECIES
321695 Danio rerio
464269 Pan troglodytes
100038255 Xenopus (Silurana) tropicalis
100157283 Sus scrofa
420212 Gallus gallus
11059 Homo sapiens
477930 Canis lupus familiaris
513789 Bos taurus
107568 Mus musculus
297930 Rattus norvegicus
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