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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Antibodies (86) and WWOX Proteins (14) and many more products for this protein.
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the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.
Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.
Aberrant WWOX expression contributes to the altered metabolism in cancer.
study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX
the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX
data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns
Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy (P = 0.045). Our data suggested the CNV-67048 to be a risk factor of epithelia ovarian cancer in Chinese women.
WW domain-containing oxidoreductase overexpression promoted apoptosis in 5637 cells and resulted in upregulation of Bax (show BAX ELISA Kits), downregulation of Bcl-2 (show BCL2 ELISA Kits), and elevated levels of cleaved caspase-3 (show CASP3 ELISA Kits) and cleaved PARP (show COL11A2 ELISA Kits), indicating activation of the intrinsic apoptosis pathway.
The SNP rs383362G >T of WWOX plays a role in chronic obstructive pulmonary disease inheritance.
a novel SNP in the intron of the WW domain-containing oxidoreductase (WWOX) gene yielded significant replicated associations with skin tanning ability
WWOX mutation is associated with early infantile epileptic encephalopathy.
Our data suggest that the loss genotypes of CNV-67048 in WWOX predispose their carriers to chronic obstructive pulmonary disease.
WWOX played roles in metabolic regulation and controlling central nervous system development. [review]
Data suggest that Pc2 (show KRT6B ELISA Kits)- (polycomb (show CBX2 ELISA Kits) repressive complex 2-) mediated SUMOylation of WWOX is essential for suppressive activity of WWOX in prostate cancer tumorigenesis.
Compared to the controls, upregulation of WWOX and its Tyr33 phosphorylation was observed in the head region of all pterygium specimens. In the head and body of the pterygium specimens, WWOX expression was significantly higher than in the controls.
Down regulation of WWOX is involved in tumorigenesis in intrahepatic cholangiocarcinoma.
Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 ELISA Kits) and Abca1 (show ABCA1 ELISA Kits) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 ELISA Kits) particles.
WWOX plays a critical role in normal central nervous system development and disease.
WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.
Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.
These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability
Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.
WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 ELISA Kits), a component of the extracellular matrix.
the WWOX tumor suppressor gene has in preventing tumorigenesis in breast cancer
analysis of the effect of the Wwox tumor suppressor gene in a knockout model
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
, WW domain-containing oxidoreductase
, retinol dehydrogenase 12
, WW domain containing oxidoreductase
, WW domain-containing protein WWOX
, fragile site FRA16D oxidoreductase
, short chain dehydrogenase/reductase family 41C, member 1
, WW-domain oxidoreductase