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WW Domain Containing Oxidoreductase Proteins (WWOX)

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Antibodies (84) and WWOX Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WWOX 51741 Q9NZC7
Mouse WWOX WWOX 80707 Q91WL8
Rat WWOX WWOX 292041  
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Top WWOX Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,144.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,151.50
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,151.50
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

WWOX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced WWOX Proteins

  1. Human WWOX Protein expressed in Escherichia coli (E. coli) - ABIN667111 : Bouteille, Driouch, Hage, Sin, Formstecher, Camonis, Lidereau, Lallemand: Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. in Oncogene 2009 (PubMed)
    Show all 2 references for ABIN667111

More Proteins for WW Domain Containing Oxidoreductase (WWOX) Interaction Partners

Fruit Fly (Drosophila melanogaster) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.

  2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.

  3. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX

  5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX

Cow (Bovine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns

Human WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. WWOX mutation is associated with early infantile epileptic encephalopathy.

  2. Our data suggest that the loss genotypes of CNV-67048 in WWOX predispose their carriers to chronic obstructive pulmonary disease.

  3. WWOX played roles in metabolic regulation and controlling central nervous system development. [review]

  4. Data suggest that Pc2 (show KRT6B Proteins)- (polycomb (show CBX2 Proteins) repressive complex 2-) mediated SUMOylation of WWOX is essential for suppressive activity of WWOX in prostate cancer tumorigenesis.

  5. Compared to the controls, upregulation of WWOX and its Tyr33 phosphorylation was observed in the head region of all pterygium specimens. In the head and body of the pterygium specimens, WWOX expression was significantly higher than in the controls.

  6. Down regulation of WWOX is involved in tumorigenesis in intrahepatic cholangiocarcinoma.

  7. Decreased WWOX expression may interfere with gemcitabine sensitivity, and allele-specific binding at rs11644332 might be a causative molecular mechanism behind the clinically observed associations.

  8. Hypermethylation of WWOX gene is associated with Epstein-Barr virus-associated gastric carcinomas.

  9. The WWOX gene can downregulate the expression levels of cell cycle proteins cyclin E (show CCNE1 Proteins)-CDK2 (show CDK2 Proteins) and cyclin D1 (show CCND1 Proteins)-CDK4 (show CDK4 Proteins), which affects the cell cycle of ovarian cancer stem cells.

  10. The inhibition of the transcriptional activity of BCL9-2 (show BCL9L Proteins) by WWOX and HDAC3 (show HDAC3 Proteins) constitutes a new molecular mechanism and provides new insight for a broad range of cancers.

Mouse (Murine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Proteins) and Abca1 (show ABCA1 Proteins) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Proteins) particles.

  2. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  3. WWOX plays a critical role in normal central nervous system development and disease.

  4. WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.

  5. Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.

  6. These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability

  7. Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.

  8. WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Proteins), a component of the extracellular matrix.

  9. the WWOX tumor suppressor gene has in preventing tumorigenesis in breast cancer

  10. analysis of the effect of the Wwox tumor suppressor gene in a knockout model

WWOX Protein Profile

Protein Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Gene names and symbols associated with WWOX

  • WW domain containing oxidoreductase (Wwox)
  • WW domain-containing oxidoreductase (Wwox)
  • WW domain containing oxidoreductase (WWOX)
  • WW domain-containing oxidoreductase (CpipJ_CPIJ004939)
  • WW domain-containing oxidoreductase (MCYG_01584)
  • WW domain-containing oxidoreductase (VDBG_05631)
  • WW domain-containing oxidoreductase (VDBG_01326)
  • WW domain-containing oxidoreductase (VDBG_06753)
  • WW domain-containing oxidoreductase (Tsp_03967)
  • WW domain-containing oxidoreductase (LOC100229880)
  • WW domain-containing oxidoreductase (LOC100284583)
  • WW domain containing oxidoreductase (wwox)
  • 5330426P09Rik protein
  • 9030416C10Rik protein
  • anon-EST:Posey177 protein
  • CG7221 protein
  • D16S432E protein
  • Dmel\\CG7221 protein
  • DmWWOX protein
  • FOR protein
  • FRA16D protein
  • GB11795 protein
  • HHCMA56 protein
  • PRO0128 protein
  • SDR41C1 protein
  • WOX1 protein
  • WWOX protein
  • zgc:55975 protein

Protein level used designations for WWOX

CG7221-PA , Wwox-PA , WW domain-containing oxidoreductase , retinol dehydrogenase 12 , WW domain containing oxidoreductase , WW domain-containing protein WWOX , fragile site FRA16D oxidoreductase , short chain dehydrogenase/reductase family 41C, member 1 , WW-domain oxidoreductase

GENE ID SPECIES
34090 Drosophila melanogaster
411815 Apis mellifera
610120 Canis lupus familiaris
618792 Bos taurus
715635 Macaca mulatta
737907 Pan troglodytes
6036407 Culex quinquefasciatus
9230790 Arthroderma otae CBS 113480
9531509 Verticillium alfalfae VaMs.102
9536255 Verticillium alfalfae VaMs.102
9537317 Verticillium alfalfae VaMs.102
10904221 Trichinella spiralis
100229880 Taeniopygia guttata
100284583 Zea mays
51741 Homo sapiens
415801 Gallus gallus
100172779 Pongo abelii
393887 Danio rerio
80707 Mus musculus
292041 Rattus norvegicus
Selected quality suppliers for WWOX Proteins (WWOX)
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