anti-WW Domain Containing Oxidoreductase (WWOX) Antibodies

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Proteins (13) and WWOX Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WWOX 51741 Q9NZC7
WWOX 80707 Q91WL8
WWOX 292041  
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Top anti-WWOX Antibodies at antibodies-online.com

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB WWOX Antibody (C-term) western blot analysis in mouse testis tissue lysates (35 µg/lane). This demonstrates the WWOX antibody detected the WWOX protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-WWOX Polyclonal Antibody (ABIN670551), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-WWOX Polyclonal Antibody , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-WWOX Antibody Titration: 1.0 ug/ml Positive Control: COLO205 Whole Cell There is BioGPS gene expression data showing that WWOX is expressed in COLO205 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB WWOX Antibody (C-term) (ABIN658713) western blot analysis in mouse testis tissue lysates (35 µg/lane). This demonstrates the WWOX antibody detected the WWOX protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using WWOX (Phospho-Tyr33) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using WWOX (Phospho-Tyr33) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells, using WWOX Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of WWOX (pY33) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incuba Western blot analysis of WWOX (pY33) expression in Raji (A), HepG2 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB <b>Western blot</b> (WB) analysis of WWOX antibody in extracts from HepG2 cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 7 to 9 Days
$451.00
Details

WWOX Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine) , ,
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, , , , ,
Rat (Rattus) ,
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Top referenced anti-WWOX Antibodies

  1. Human Polyclonal WWOX Primary Antibody for IHC - ABIN967262 : Bednarek, Laflin, Daniel, Liao, Hawkins, Aldaz: WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. in Cancer research 2000 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal WWOX Primary Antibody for IF (p), IHC (p) - ABIN670551 : Zhang, Zhang, Cong, Zhang: The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients. in Diagnostic pathology 2013 (PubMed)

More Antibodies against WWOX Interaction Partners

Fruit Fly (Drosophila melanogaster) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.

  2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.

  3. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX

  5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX

Cow (Bovine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns

Human WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. genetic variations in WWOX may be a significant predictor of early HCC (show FAM126A Antibodies) occurrence and a reliable biomarker for disease progression

  2. a WWOX-p53 (show TP53 Antibodies) network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma.

  3. Low WWOX expression is associated with Head and Neck Squamous Cell Carcinoma.

  4. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun (show JUN Antibodies)- and IL-8 (show IL8 Antibodies)-dependent neutrophil chemotaxis toward cell monolayers.

  5. a portion of ERK (show EPHB2 Antibodies) and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 (show CD3 Antibodies) and CD8 (show CD8A Antibodies) expression in MOLT-4.

  6. Brca1-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells

  7. Epigenetic mechanisms influence molecular patterns important for the bone-metastatic process, and this review highlights the role of WW-domain containing oxidoreductase (Wwox). [review]

  8. the deregulation of microRNA-214-3p expression is involved in a negative feedback loop with WWOX in osteosarcoma, indicating that miR (show MLXIP Antibodies)-214-3p has potential basic and clinical implications.

  9. Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy (P = 0.045). Our data suggested the CNV-67048 to be a risk factor of epithelia ovarian cancer in Chinese women.

  10. WW domain-containing oxidoreductase overexpression promoted apoptosis in 5637 cells and resulted in upregulation of Bax (show BAX Antibodies), downregulation of Bcl-2 (show BCL2 Antibodies), and elevated levels of cleaved caspase-3 (show CASP3 Antibodies) and cleaved PARP (show COL11A2 Antibodies), indicating activation of the intrinsic apoptosis pathway.

Mouse (Murine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun (show JUN Antibodies)- and IL-8 (show IL8 Antibodies)-dependent neutrophil chemotaxis toward cell monolayers.

  2. Brca1 (show BRCA1 Antibodies)-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells

  3. Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Antibodies) and Abca1 (show ABCA1 Antibodies) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Antibodies) particles.

  4. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  5. WWOX plays a critical role in normal central nervous system development and disease.

  6. WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.

  7. Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.

  8. These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability

  9. Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.

  10. WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Antibodies), a component of the extracellular matrix.

WWOX Antigen Profile

Protein Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Gene names and symbols associated with WWOX

  • WW domain containing oxidoreductase (Wwox) antibody
  • WW domain-containing oxidoreductase (Wwox) antibody
  • WW domain containing oxidoreductase (WWOX) antibody
  • WW domain-containing oxidoreductase (CpipJ_CPIJ004939) antibody
  • WW domain-containing oxidoreductase (MCYG_01584) antibody
  • WW domain-containing oxidoreductase (VDBG_05631) antibody
  • WW domain-containing oxidoreductase (VDBG_01326) antibody
  • WW domain-containing oxidoreductase (VDBG_06753) antibody
  • WW domain-containing oxidoreductase (Tsp_03967) antibody
  • WW domain-containing oxidoreductase (LOC100229880) antibody
  • WW domain-containing oxidoreductase (LOC100284583) antibody
  • WW domain containing oxidoreductase (wwox) antibody
  • 5330426P09Rik antibody
  • 9030416C10Rik antibody
  • anon-EST:Posey177 antibody
  • CG7221 antibody
  • D16S432E antibody
  • Dmel\\CG7221 antibody
  • DmWWOX antibody
  • FOR antibody
  • FRA16D antibody
  • GB11795 antibody
  • HHCMA56 antibody
  • PRO0128 antibody
  • SDR41C1 antibody
  • WOX1 antibody
  • WWOX antibody
  • zgc:55975 antibody

Protein level used designations for WWOX

CG7221-PA , Wwox-PA , WW domain-containing oxidoreductase , retinol dehydrogenase 12 , WW domain containing oxidoreductase , WW domain-containing protein WWOX , fragile site FRA16D oxidoreductase , short chain dehydrogenase/reductase family 41C, member 1 , WW-domain oxidoreductase

GENE ID SPECIES
34090 Drosophila melanogaster
411815 Apis mellifera
610120 Canis lupus familiaris
618792 Bos taurus
715635 Macaca mulatta
737907 Pan troglodytes
6036407 Culex quinquefasciatus
9230790 Arthroderma otae CBS 113480
9531509 Verticillium alfalfae VaMs.102
9536255 Verticillium alfalfae VaMs.102
9537317 Verticillium alfalfae VaMs.102
10904221 Trichinella spiralis
100229880 Taeniopygia guttata
100284583 Zea mays
51741 Homo sapiens
415801 Gallus gallus
100172779 Pongo abelii
393887 Danio rerio
80707 Mus musculus
292041 Rattus norvegicus
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