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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Proteins (13) and WWOX Kits (7) and many more products for this protein.
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Human Polyclonal WWOX Primary Antibody for IHC - ABIN967262
Bednarek, Laflin, Daniel, Liao, Hawkins, Aldaz: WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. in Cancer research 2000
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Human Polyclonal WWOX Primary Antibody for IF (p), IHC (p) - ABIN670551
Zhang, Zhang, Cong, Zhang: The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients. in Diagnostic pathology 2013
the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.
Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.
Aberrant WWOX expression contributes to the altered metabolism in cancer.
study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX
the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX
data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns
genetic variations in WWOX may be a significant predictor of early HCC (show FAM126A Antibodies) occurrence and a reliable biomarker for disease progression
a WWOX-p53 (show TP53 Antibodies) network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma.
Low WWOX expression is associated with Head and Neck Squamous Cell Carcinoma.
Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun (show JUN Antibodies)- and IL-8 (show IL8 Antibodies)-dependent neutrophil chemotaxis toward cell monolayers.
a portion of ERK (show EPHB2 Antibodies) and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 (show CD3 Antibodies) and CD8 (show CD8A Antibodies) expression in MOLT-4.
Brca1-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells
Epigenetic mechanisms influence molecular patterns important for the bone-metastatic process, and this review highlights the role of WW-domain containing oxidoreductase (Wwox). [review]
the deregulation of microRNA-214-3p expression is involved in a negative feedback loop with WWOX in osteosarcoma, indicating that miR (show MLXIP Antibodies)-214-3p has potential basic and clinical implications.
Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy (P = 0.045). Our data suggested the CNV-67048 to be a risk factor of epithelia ovarian cancer in Chinese women.
WW domain-containing oxidoreductase overexpression promoted apoptosis in 5637 cells and resulted in upregulation of Bax (show BAX Antibodies), downregulation of Bcl-2 (show BCL2 Antibodies), and elevated levels of cleaved caspase-3 (show CASP3 Antibodies) and cleaved PARP (show COL11A2 Antibodies), indicating activation of the intrinsic apoptosis pathway.
Brca1 (show BRCA1 Antibodies)-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells
Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Antibodies) and Abca1 (show ABCA1 Antibodies) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Antibodies) particles.
WWOX plays a critical role in normal central nervous system development and disease.
WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.
Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.
These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability
Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.
WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Antibodies), a component of the extracellular matrix.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
, WW domain-containing oxidoreductase
, retinol dehydrogenase 12
, WW domain containing oxidoreductase
, WW domain-containing protein WWOX
, fragile site FRA16D oxidoreductase
, short chain dehydrogenase/reductase family 41C, member 1
, WW-domain oxidoreductase