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WW and C2 Domain Containing 1 Proteins (WWC1)

The protein encoded by WWC1 is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Additionally we are shipping WW and C2 Domain Containing 1 Antibodies (46) and WW and C2 Domain Containing 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WWC1 23286 Q8IX03
WWC1 211652 Q5SXA9
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Top WW and C2 Domain Containing 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$510.36
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

WWC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for WW and C2 Domain Containing 1 (WWC1) Interaction Partners

Fruit Fly (Drosophila melanogaster) WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. Kibra, a binding partner of Pez, stabilizes Pez via WW-PY/PPxY interaction.

  2. Kibra regulates starvation-induced autophagy downstream of aPKC.

  3. In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.

  4. The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.

  5. Kibra functions as a tumor suppressor protein (show TP53 Proteins) that regulates Hippo signaling in conjunction with Merlin (show NF2 Proteins) and Expanded.

  6. Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

  7. Kibra predominantly acts in the Merlin (show NF2 Proteins) branch upstream of the core kinase cascade to regulate Hippo signaling.

Human WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. Study observed a trend for a better memory performance and significantly higher volumes and better microstructural integrity in the subfields comprising the CA2 (show CA2 Proteins)/3 and CA4 (show CA4 Proteins)/DG of the hippocampus in KIBRA T-allele carriers compared with non-T-carriers

  2. decreased expression of the KIBRA gene on both mRNA and protein levels in depression, is reported.

  3. Phosphorylation-dependent regulation of the DNA damage response of Kibra protein in cancer cells

  4. Study did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in older adults

  5. KIBRA rs17070145 affects specific phenotypes (high alcohol consumption, APOE (show APOE Proteins) synergism) of Japanese patients with Alzheimer disease in an age-dependent manner. Right inferior frontal gyrus hyperperfusion was seen in the C allele carrier group.

  6. the study demonstrates an association between the KIBRA gene and episodic memory (immediate free recall) and suggests a differential effect of this genetic variant in early-onset schizophrenia and healthy siblings

  7. In brief, we showed that individuals with MD[major depression] that were WWC1 rs17070145TT carriers reported more severe 'concentration difficulties' than C-carriers.

  8. The results of this study supports the view that effects of KIBRA and CLSTN2 polymorphisms genetic polymorphisms on cognitive functioning may be most easily disclosed at suboptimal levels of cognitive ability, such as in old-age depression.

  9. KIBRA is involved in human tumorigenesis and other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration.

  10. KIBRA/WWC1 rs17070145 polymorphism has effect on spatial memory in humans and age differences in the reliance on landmark and boundary-related spatial information.

Mouse (Murine) WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta

  2. These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.

  3. KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  4. KIBRA functions in memory performance via interaction with PKMzeta.

WW and C2 Domain Containing 1 (WWC1) Protein Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with WWC1

  • kibra ortholog (kibra)
  • WW and C2 domain containing 1 (WWC1)
  • WW, C2 and coiled-coil domain containing 1 (Wwc1)
  • AA408228 protein
  • AU017197 protein
  • BC037006 protein
  • CG7552 protein
  • CG12600 protein
  • CG33967 protein
  • Dmel\\CG33967 protein
  • HBEBP3 protein
  • HBEBP36 protein
  • kib protein
  • KIBRA protein
  • l(3)02404 protein
  • l(3)j5C3 protein
  • l(3)neo42 protein
  • mKIAA0869 protein
  • ORE-2 protein
  • RE26350 protein

Protein level used designations for WWC1

CG33967-PA , kibra-PA , lethal (3) neo42 , HBeAg-binding protein 3 , WW, C2 and coiled-coil domain containing 1 , kidney and brain protein , protein KIBRA , protein WWC1 , WW domain-containing protein 1

GENE ID SPECIES
41783 Drosophila melanogaster
23286 Homo sapiens
211652 Mus musculus
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