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The protein encoded by WWC1 is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Additionally we are shipping WW and C2 Domain Containing 1 Antibodies (46) and WW and C2 Domain Containing 1 Kits (7) and many more products for this protein.
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Kibra, a binding partner of Pez, stabilizes Pez via WW-PY/PPxY interaction.
Kibra regulates starvation-induced autophagy downstream of aPKC.
In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.
The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.
Kibra functions as a tumor suppressor protein (show TP53 Proteins) that regulates Hippo signaling in conjunction with Merlin (show NF2 Proteins) and Expanded.
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
Kibra predominantly acts in the Merlin (show NF2 Proteins) branch upstream of the core kinase cascade to regulate Hippo signaling.
Study observed a trend for a better memory performance and significantly higher volumes and better microstructural integrity in the subfields comprising the CA2 (show CA2 Proteins)/3 and CA4 (show CA4 Proteins)/DG of the hippocampus in KIBRA T-allele carriers compared with non-T-carriers
decreased expression of the KIBRA gene on both mRNA and protein levels in depression, is reported.
Phosphorylation-dependent regulation of the DNA damage response of Kibra protein in cancer cells
Study did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in older adults
KIBRA rs17070145 affects specific phenotypes (high alcohol consumption, APOE (show APOE Proteins) synergism) of Japanese patients with Alzheimer disease in an age-dependent manner. Right inferior frontal gyrus hyperperfusion was seen in the C allele carrier group.
the study demonstrates an association between the KIBRA gene and episodic memory (immediate free recall) and suggests a differential effect of this genetic variant in early-onset schizophrenia and healthy siblings
In brief, we showed that individuals with MD[major depression] that were WWC1 rs17070145TT carriers reported more severe 'concentration difficulties' than C-carriers.
The results of this study supports the view that effects of KIBRA and CLSTN2 polymorphisms genetic polymorphisms on cognitive functioning may be most easily disclosed at suboptimal levels of cognitive ability, such as in old-age depression.
KIBRA is involved in human tumorigenesis and other physiological processes including cell polarity, membrane/vesicular trafficking, mitosis and cell migration.
KIBRA/WWC1 rs17070145 polymorphism has effect on spatial memory in humans and age differences in the reliance on landmark and boundary-related spatial information.
KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.
KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif
KIBRA functions in memory performance via interaction with PKMzeta.
The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.
, lethal (3) neo42
, HBeAg-binding protein 3
, WW, C2 and coiled-coil domain containing 1
, kidney and brain protein
, protein KIBRA
, protein WWC1
, WW domain-containing protein 1