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anti-Werner Helicase Interacting Protein 1 (WRNIP1) Antibodies

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). Additionally we are shipping WRNIP1 Kits (3) and WRNIP1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WRNIP1 56897 Q96S55
WRNIP1 78903 Q91XU0
WRNIP1 282835 Q8CG07
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Top anti-WRNIP1 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-WRNIP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate Sample Type: HeLa cell lysate  Dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, WB AP31060PU-N WRNIP1 antibody staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. AP31060PU-N WRNIP1 antibody staining of Jurkat lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB WRNIP1 Antibody (N-term)  western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the WRNIP1 antibody detected the WRNIP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis is shown using Affinity Purified anti-Human WHIP antibody to detect Human WHIP present in a HEK293 whole cell lysate.  ~30µg of lysate was loaded per lane for 4-20% gradient SDS-PAGE.  Comparison to a molecular weight marker (not shown) indicates a primary band of ~96.0 kDa is detected.  The identity of the minor band migrating at a slightly higher molecular weight is unknown, but may represent an alternate isoform of WHIP or post translational modification of the WHIP protein.  See Figure 2 for the results of peptide competition experiments. The blot was incubated with a 1:200 dilution of the antibody at room temperature for 2 h followed by detection using IRDye® 800 labeled Goat-a-Rabbit IgG [H&L] MX10 (611-132-122) diluted 1:5,000 for 45 min.  IRDye® 800 fluorescence image was captured using the Odyssey® Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc.  Other detection systems will yield similar results. Western blot analysis is shown using antibodies-online's anti-Human WHIP antibody with and without pre-incubation with blocking peptide. Testing was performed on antiserum prior to affinity purification. Peptide competition (left) blocks the specific staining, whereas the control (right) shows staining of a strong dominant band corresponding to human WHIP1. ~30ug of HEK293 lysate was loaded per lane for 4-20% gradient SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a band of ~96.0 kDa is detected. The blot was incubated with a 1:1000 dilution of the antibody at room temperature for 2 h followed by detection using IRDye 100 μg Log in to see 2 to 3 Days
$369.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC (p), WB Human Testis (formalin-fixed, paraffin-embedded) stained with WRNIP1 antibody ABIN214570 at 3 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Breast (formalin-fixed, paraffin-embedded) stained with WRNIP1 antibody ABIN214570 at 3 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$676.50
Details

WRNIP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
,

, , , , ,
Mouse (Murine)
,

Rat (Rattus)
,

Top referenced anti-WRNIP1 Antibodies

  1. Cow (Bovine) Polyclonal WRNIP1 Primary Antibody for WB - ABIN2775244 : Tsurimoto, Shinozaki, Yano, Seki, Enomoto: Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. in Genes to cells : devoted to molecular & cellular mechanisms 2005 (PubMed)

  2. Human Polyclonal WRNIP1 Primary Antibody for IHC, ELISA - ABIN184613 : Kawabe Yi, Branzei, Hayashi, Suzuki, Masuko, Onoda, Heo, Ikeda, Shimamoto, Furuichi, Seki, Enomoto: A novel protein interacts with the Werner's syndrome gene product physically and functionally. in The Journal of biological chemistry 2001 (PubMed)

More Antibodies against WRNIP1 Interaction Partners

Human Werner Helicase Interacting Protein 1 (WRNIP1) interaction partners

  1. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation

  2. Mutated WRNIP1 with a deleted ATPase (show DNAH8 Antibodies) domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase (show DNAH8 Antibodies) domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.

  3. WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC (show NPC1 Antibodies)) and set forth to investigate a role for the protein positioned at the NPC (show NPC1 Antibodies).

  4. These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta (show POLD1 Antibodies)-mediated DNA synthesis and that its ATPase (show DNAH8 Antibodies) activity is utilized to sense DNA ends and to regulate the extent of stimulation.

  5. Werner helicase-interacting protein 1 binds polyubiquitin (show UBB Antibodies) via its zinc finger domain

  6. analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions

  7. Data show that that WRNIP1 interacts physically with RAD18 (show RAD18 Antibodies) and interferes with the binding of RAD18 (show RAD18 Antibodies) to forked DNA and to template/primer DNA.

Mouse (Murine) Werner Helicase Interacting Protein 1 (WRNIP1) interaction partners

  1. Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.

WRNIP1 Antigen Profile

Protein Summary

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Gene names and symbols associated with WRNIP1

  • Werner helicase interacting protein 1 (WRNIP1) antibody
  • Werner helicase interacting protein 1 (wrnip1) antibody
  • ATPase WRNIP1 (EDI_075920) antibody
  • ATPase WRNIP1 (CpipJ_CPIJ017857) antibody
  • ATPase WRNIP1 (PITG_07216) antibody
  • ATPase WRNIP1 (VDBG_02914) antibody
  • ATPase WRNIP1 (PGTG_08805) antibody
  • Werner helicase interacting protein 1 (Wrnip1) antibody
  • WRNIP1 protein (LOC100155921) antibody
  • 4833444L21Rik antibody
  • bA420G6.2 antibody
  • RP11-420G6.2 antibody
  • Whip antibody
  • Wrnip antibody
  • wrnip1 antibody
  • zgc:85976 antibody

Protein level used designations for WRNIP1

Werner helicase interacting protein 1 , ATPase WRNIP1 , Werner helicase-interacting protein 1 , putative helicase RUVBL , Werner helicasae interacting protein 1 , Werner syndrome homolog interacting protein , werner helicase-interacting protein 1

GENE ID SPECIES
462392 Pan troglodytes
707250 Macaca mulatta
734231 Xenopus laevis
782711 Bos taurus
395089 Gallus gallus
100158593 Xenopus (Silurana) tropicalis
5882536 Entamoeba dispar SAW760
6052914 Culex quinquefasciatus
9471556 Phytophthora infestans T30-4
9532917 Verticillium alfalfae VaMs.102
10529992 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100595079 Nomascus leucogenys
56897 Homo sapiens
405856 Danio rerio
788824 Bos taurus
78903 Mus musculus
282835 Rattus norvegicus
100155921 Sus scrofa
Selected quality suppliers for anti-WRNIP1 (WRNIP1) Antibodies
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