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Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). Additionally we are shipping WRNIP1 Antibodies (64) and WRNIP1 Proteins (3) and many more products for this protein.
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results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation
Mutated WRNIP1 with a deleted ATPase (show DNAH8 ELISA Kits) domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase (show DNAH8 ELISA Kits) domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.
WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC (show NPC1 ELISA Kits)) and set forth to investigate a role for the protein positioned at the NPC (show NPC1 ELISA Kits).
These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta (show POLD1 ELISA Kits)-mediated DNA synthesis and that its ATPase (show DNAH8 ELISA Kits) activity is utilized to sense DNA ends and to regulate the extent of stimulation.
Werner helicase-interacting protein 1 binds polyubiquitin (show UBB ELISA Kits) via its zinc finger domain
analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions
Data show that that WRNIP1 interacts physically with RAD18 (show RAD18 ELISA Kits) and interferes with the binding of RAD18 (show RAD18 ELISA Kits) to forked DNA and to template/primer DNA.
Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
Werner helicase interacting protein 1
, ATPase WRNIP1
, Werner helicase-interacting protein 1
, putative helicase RUVBL
, Werner helicasae interacting protein 1
, Werner syndrome homolog interacting protein
, werner helicase-interacting protein 1