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Werner Helicase Interacting Protein 1 Proteins (WRNIP1)

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). Additionally we are shipping WRNIP1 Antibodies (61) and WRNIP1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WRNIP1 56897 Q96S55
Mouse WRNIP1 WRNIP1 78903 Q91XU0
WRNIP1 282835 Q8CG07
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Top WRNIP1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,916.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

WRNIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Rat (Rattus)

More Proteins for Werner Helicase Interacting Protein 1 (WRNIP1) Interaction Partners

Human Werner Helicase Interacting Protein 1 (WRNIP1) interaction partners

  1. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation

  2. Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.

  3. WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC (show NPC1 Proteins)) and set forth to investigate a role for the protein positioned at the NPC (show NPC1 Proteins).

  4. These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta-mediated DNA synthesis and that its ATPase activity is utilized to sense DNA ends and to regulate the extent of stimulation.

  5. Werner helicase-interacting protein 1 binds polyubiquitin (show UBB Proteins) via its zinc finger domain

  6. analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions

  7. Data show that that WRNIP1 interacts physically with RAD18 (show RAD18 Proteins) and interferes with the binding of RAD18 (show RAD18 Proteins) to forked DNA and to template/primer DNA.

Mouse (Murine) Werner Helicase Interacting Protein 1 (WRNIP1) interaction partners

  1. Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.

WRNIP1 Protein Profile

Protein Summary

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

Gene names and symbols associated with WRNIP1

  • Werner helicase interacting protein 1 (WRNIP1)
  • Werner helicase interacting protein 1 (wrnip1)
  • ATPase WRNIP1 (EDI_075920)
  • ATPase WRNIP1 (CpipJ_CPIJ017857)
  • ATPase WRNIP1 (PITG_07216)
  • ATPase WRNIP1 (VDBG_02914)
  • ATPase WRNIP1 (PGTG_08805)
  • Werner helicase interacting protein 1 (Wrnip1)
  • WRNIP1 protein (LOC100155921)
  • 4833444L21Rik protein
  • bA420G6.2 protein
  • RP11-420G6.2 protein
  • Whip protein
  • Wrnip protein
  • wrnip1 protein
  • zgc:85976 protein

Protein level used designations for WRNIP1

Werner helicase interacting protein 1 , ATPase WRNIP1 , Werner helicase-interacting protein 1 , putative helicase RUVBL , Werner helicasae interacting protein 1 , Werner syndrome homolog interacting protein , werner helicase-interacting protein 1

GENE ID SPECIES
462392 Pan troglodytes
707250 Macaca mulatta
734231 Xenopus laevis
782711 Bos taurus
395089 Gallus gallus
100158593 Xenopus (Silurana) tropicalis
5882536 Entamoeba dispar SAW760
6052914 Culex quinquefasciatus
9471556 Phytophthora infestans T30-4
9532917 Verticillium alfalfae VaMs.102
10529992 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100595079 Nomascus leucogenys
56897 Homo sapiens
405856 Danio rerio
788824 Bos taurus
78903 Mus musculus
282835 Rattus norvegicus
100155921 Sus scrofa
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