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WBSCR22 encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. Additionally we are shipping WBSCR22 Proteins (5) and many more products for this protein.
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Human Polyclonal WBSCR22 Primary Antibody for WB - ABIN1881998
Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. in Genomics 2007
Show all 5 references for ABIN1881998
Human Polyclonal WBSCR22 Primary Antibody for ICC, IF - ABIN4365943
Zorbas, Nicolas, Wacheul, Huvelle, Heurgué-Hamard, Lafontaine: The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. in Molecular biology of the cell 2015
Human Polyclonal WBSCR22 Primary Antibody for ICC, IF - ABIN441457
Nakazawa, Arai, Fujita: The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. in Cancer research 2011
The localization of the TRMT112 (show TRMT112 Antibodies) protein is determined by WBSCR22, and the WBSCR22-TRMT112 (show TRMT112 Antibodies) complex is localized in the cell nucleus.
DIMT1L (show DIMT1 Antibodies) and WBSCR22-TRMT112 (show TRMT112 Antibodies) are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity.
Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 (show TP53 Antibodies) expression levels.
The key role of WBSCR22 in 40S subunit (show RPS21 Antibodies) biogenesis is independent of its function as an RNA methyltransferase.
WBSCR22 protein level is decreased in lymphoblastoid cell lines.
Merm1 is a novel regulator of chromatin structure affecting GR recruitment and function
Characterization of two novel genes, WBSCR20 (show NSUN5 Antibodies) and WBSCR22, deleted in Williams-Beuren syndrome
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found.
Williams Beuren syndrome chromosome region 22 protein
, Williams Beuren syndrome chromosome region 22
, hypothetical protein LOC496966
, williams Beuren syndrome chromosome region 22
, Williams-Beuren candidate region putative methyltransferase
, Williams-Beuren syndrome chromosomal region 22 protein
, metastasis-related methyltransferase 1
, uncharacterized methyltransferase WBSCR22
, Williams-Beuren syndrome chromosomal region 22 protein homolog