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WBSCR22 encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. Additionally we are shipping WBSCR22 Antibodies (41) and many more products for this protein.
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The localization of the TRMT112 (show TRMT112 Proteins) protein is determined by WBSCR22, and the WBSCR22-TRMT112 (show TRMT112 Proteins) complex is localized in the cell nucleus.
DIMT1L (show DIMT1 Proteins) and WBSCR22-TRMT112 (show TRMT112 Proteins) are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity.
Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 (show TP53 Proteins) expression levels.
The key role of WBSCR22 in 40S subunit (show RPS21 Proteins) biogenesis is independent of its function as an RNA methyltransferase.
WBSCR22 protein level is decreased in lymphoblastoid cell lines.
Merm1 is a novel regulator of chromatin structure affecting GR recruitment and function
Characterization of two novel genes, WBSCR20 (show NSUN5 Proteins) and WBSCR22, deleted in Williams-Beuren syndrome
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found.
Williams Beuren syndrome chromosome region 22 protein
, Williams Beuren syndrome chromosome region 22
, hypothetical protein LOC496966
, williams Beuren syndrome chromosome region 22
, Williams-Beuren candidate region putative methyltransferase
, Williams-Beuren syndrome chromosomal region 22 protein
, metastasis-related methyltransferase 1
, uncharacterized methyltransferase WBSCR22
, Williams-Beuren syndrome chromosomal region 22 protein homolog