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Wilms Tumor 1 Homolog Proteins (WT1)

WT1 encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus.

list all proteins Gene Name GeneID UniProt
WT1 24883 P49952
Mouse WT1 WT1 22431  
WT1    
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Top WT1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
Yeast Sminthopsis macroura His tag 1 mg Log in to see 56 to 66 Days
$2,607.00
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Yeast Alligator His tag 1 mg Log in to see 56 to 66 Days
$2,759.17
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Yeast Rat His tag 1 mg Log in to see 56 to 66 Days
$3,256.00
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Yeast Wild boar His tag 1 mg Log in to see 56 to 66 Days
$3,259.67
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Yeast Xenopus tropicalis His tag 1 mg Log in to see 56 to 66 Days
$3,147.83
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WT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

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More Proteins for Wilms Tumor 1 Homolog (WT1) Interaction Partners

Pig (Porcine) Wilms Tumor 1 Homolog (WT1) interaction partners

  1. Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.

  2. Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.

  3. WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts

Mouse (Murine) Wilms Tumor 1 Homolog (WT1) interaction partners

  1. miR (show MLXIP Proteins)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR of WT1 mRNA and miR (show MLXIP Proteins)-125a knockout mice induce myeloproliferative disease (MPD (show MVD Proteins)) and urogenital abnormalities

  2. The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.

  3. During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21 (show TCF21 Proteins)-LacZ (show GLB1 Proteins) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.

  4. Wt1 is essential for normal development at all kidney developmental stages under study.

  5. Wt1 expression levels in podocytes regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling through modulating the endocytic fate of LRP6 (show LRP6 Proteins), and this indicates a potential target for the therapy of CKD.

  6. The results suggest a possible role for Wt1 in cardiac vessel formation in development and disease.

  7. Conditional beta-catenin (show CTNNB1 Proteins) loss phenocopies the Wt1 mutant diaphragm defect, while constitutive activation of beta-catenin (show CTNNB1 Proteins) on the Wt1 mutant background is sufficient to close the diaphragm defect

  8. WT1 modulates receptor tyrosine kinase (show ERBB3 Proteins) signaling in nephron progenitor cell by directing the expression of Gas1 (show GAS1 Proteins).

  9. WT1 can modulate LHbeta (show LHB Proteins) transcription with differential roles for the two WT1 variants

  10. the results of this study demonstrate a novel association between fibrocyte-driven WT1(+) cell accumulation and severe fibrotic lung disease.

WT1 Protein Profile

Protein Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms.

Gene names and symbols associated with Wilms Tumor 1 Homolog Proteins (WT1)

  • Wilms tumor 1 (WT1)
  • Wilms tumor 1 (Wt1)
  • Wilms tumor 1 homolog (Wt1)
  • D630046I19Rik protein
  • Wt-1 protein

Protein level used designations for Wilms Tumor 1 Homolog Proteins (WT1)

Wilms tumor protein homolog

GENE ID SPECIES
397338 Sus scrofa
24883 Rattus norvegicus
22431 Mus musculus
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