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Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Additionally we are shipping WTIP Antibodies (23) and WTIP Kits (3) and many more products for this protein.
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WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.
Wtip regulates the stable formation of cell adhesions to both extracellular matrix and neighboring cells and suggest that Wtip is necessary for normal glomerular filtration barrier function
Report role of WTIP in regulating podocyte phenotype in chronic kidney disease.
Full-length Ror2 (show ROR2 Proteins) recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo.
WTIP is a member of the Ajuba (show AJUBA Proteins) family of LIM (show PDLIM5 Proteins)-domain containing proteins. Ajuba (show AJUBA Proteins) LIM (show PDLIM5 Proteins) proteins co-repress E-cadherin (show CDH1 Proteins) expression through interaction with the SNAG domain of Snail (show SNAI1 Proteins)/Slug (show SNAI2 Proteins) and promote epithelial to mesenchymal differentiation in a Xenopus model.
Stress signaling pathways initiate WTIP nuclear translocation, and the concomitant loss of WTIP from cell contacts changes podocyte morphology and dynamic actin assembly, suggesting a mechanism that transmits changes in podocyte morphology to the nucleus.
WTIP monitors slit diaphragm protein assembly as part of a multiple protein complex, linking this specialized adhesion junction to the actin cytoskeleton, and shuttles into the nucleus after podocyte injury
implicate Asxl1 (show ASXL1 Proteins) in the maintenance of podocyte structure via its association with Wtip and in the regulation of WT1 (show WT1 Proteins) signaling during early kidney development
ASXL2 and WTIP are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP participate in regulation of retinoic acid signaling during heart development.
Dendrin is dispensable for the function of the normal glomerular filtration barrier, and it interacts with Wtip and Gadd45a (show GADD45A Proteins).
Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport
Full-length Ror2 (show ROR2 Proteins) recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so.
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1- dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.
, Wilms tumor protein 1-interacting protein
, Wilms tumor protein 1-interacting protein homolog
, WT1-interacting protein homolog
, Wilms tumor 1 interacting protein