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anti-Wings Apart-Like Protein Homolog (WAPAL) Antibodies

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WAPAL 290577  
WAPAL 23063 Q7Z5K2
WAPAL 218914 Q65Z40
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Top anti-WAPAL Antibodies at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western Blot analysis of KIAA0261 expression in transfected 293T cell line by KIAA0261 monoclonal antibody (M02), clone 2B3. Lane 1: KIAA0261 transfected lysate(45.6 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged KIAA0261 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-WAPL Polyclonal Antibody, Unconjugated (ABIN872457) at 1:200 followed by conjugation to the secondary antibody 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-WAPAL / WAPL antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1105033 dilution 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IP Immunoprecipitation of WAPAL transfected lysate using anti-WAPAL MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with WAPAL purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of WAPAL expression in transfected 293T cell line by WAPAL MaxPab polyclonal antibody.Lane 1: KIAA0261 transfected lysate(44.22 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to KIAA0261 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IP, ELISA, WB Western Blot analysis of KIAA0261 expression in transfected 293T cell line by KIAA0261 monoclonal antibody (M02), clone 2B3.Lane 1: KIAA0261 transfected lysate(45.6 KDa).Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged KIAA0261 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF, ELISA   100 μg Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 11 to 13 Days
$541.80
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$859.83
Details
Human Rabbit Un-conjugated PLA, WB   100 μL Log in to see 8 to 10 Days
$595.83
Details

WAPAL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Human , , , ,
,
,
Mouse (Murine)


More Antibodies against WAPAL Interaction Partners

Human Wings Apart-Like Protein Homolog (WAPAL) interaction partners

  1. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53 (show TP53 Antibodies)-dependent manner but causes p53 (show TP53 Antibodies)-deficient cells to become highly aneuploid.

  2. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin

  3. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21 (show NSMCE2 Antibodies)-deficient or Scc1 (show PTPRJ Antibodies) mutant-expressing cells

  4. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain.

  5. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits

  6. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin.

  7. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.

  8. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder.

Mouse (Murine) Wings Apart-Like Protein Homolog (WAPAL) interaction partners

  1. High levels of WAPAL are observed in human cervical cancers, and expression of human WAPAL in mice causes tumor formation.

  2. in mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling mitotic exit in the presence of functional cohesin complexes

  3. mWAPL may be involved in spermatogenesis and be target genes mediating the reproductive toxicity induced by 2,3,7,8-trachlorodibenzo-p-dioxin .

WAPAL Antigen Profile

Protein Summary

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).

Gene names and symbols associated with WAPAL

  • wings apart-like homolog (Drosophila) (Wapal) antibody
  • wings apart-like homolog (Drosophila) (WAPAL) antibody
  • wings apart-like protein homolog (LOC100408201) antibody
  • wings apart-like protein homolog (LOC100475548) antibody
  • wings apart-like homolog (Drosophila) (wapal) antibody
  • wings apart-like protein homolog (LOC100581674) antibody
  • 2410073G16 antibody
  • A530089A20Rik antibody
  • BC037674 antibody
  • FOE antibody
  • KIAA0261 antibody
  • mKIAA0261 antibody
  • mWAPL antibody
  • RGD1308960 antibody
  • WAPL antibody

Protein level used designations for WAPAL

wings apart-like protein homolog , wings apart-like homolog (Drosophila) , WAPL family member (wapl-1)-like , friend of EBNA2 (Epstein-Barr virus nuclear protein 2) , friend of EBNA2 protein , DIF-2 , WAPL protein , dioxin-inducible factor 2 , friend of EBNA2

GENE ID SPECIES
290577 Rattus norvegicus
423608 Gallus gallus
534322 Bos taurus
100408201 Callithrix jacchus
100452617 Pongo abelii
100475548 Ailuropoda melanoleuca
100546200 Meleagris gallopavo
100553268 Anolis carolinensis
100581674 Nomascus leucogenys
23063 Homo sapiens
218914 Mus musculus
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