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Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Additionally we are shipping WLS Proteins (5) and many more products for this protein.
Showing 10 out of 26 products:
Chicken Polyclonal WLS Primary Antibody for WB - ABIN2781860
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
This study has revealed a strong association between the expression of WLS and HER2 (show ERBB2 Antibodies) that has important biological and clinical implications.
This study identified CMTM8 (show CMTM8 Antibodies) as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene (show RAB1A Antibodies) in osteosarcoma.
GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia.
endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi.
Colorectal tumors express elevated levels of Wnt3 and GPR177.
The data suggest that the common variants of WLS analyzed in this study are not associated with opioid or cocaine addiction.
Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.
findings lead to a proposed mechanism by which Gpr177 controls skeletal development through modulation of autocrine and paracrine Wnt (show WNT2 Antibodies) signals in a lineage-specific fashion
WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signalling.
The Evi/Wls overexpression is sufficient to promote downstream Wnt signalling.
these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt (show WNT2 Antibodies) ligands.
regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt (show WNT2 Antibodies) signaling
Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.
Wls-mediated secretion of Wnt (show WNT2 Antibodies) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.
eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (show WNT2 Antibodies) activity, leading to inhibition of odontoblast maturation and root elongation.
The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (show ATOH1 Antibodies), and Pax6 (show PAX6 Antibodies) in the rhombic lip provides novel views of early cerebellar development.
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium
The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt (show WNT2 Antibodies) proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development.
Gpr177 regulates pulmonary vasculature development.
Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.
The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (show WNT2 Antibodies) secretion in a variety of embryonic and adult tissue types.
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
G protein-coupled receptor 177
, integral membrane protein GPR177
, protein evenness interrupted homolog
, protein wntless homolog
, putative NF-kappa-B-activating protein 373
, putative NFkB activating protein 373