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Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Additionally we are shipping WLS Antibodies (13) and WLS Proteins (5) and many more products for this protein.
Genetic variation at the WLS and CCDC170 (show CCDC170 ELISA Kits)/ESR1 (show ESR1 ELISA Kits) loci were found to be significantly associated with bone mineral density
This study has revealed a strong association between the expression of WLS and HER2 (show ERBB2 ELISA Kits) that has important biological and clinical implications.
This study identified CMTM8 (show CMTM8 ELISA Kits) as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene (show RAB1A ELISA Kits) in osteosarcoma.
GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia.
endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi.
Colorectal tumors express elevated levels of Wnt3 and GPR177.
The data suggest that the common variants of WLS analyzed in this study are not associated with opioid or cocaine addiction.
Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.
findings lead to a proposed mechanism by which Gpr177 controls skeletal development through modulation of autocrine and paracrine Wnt (show WNT2 ELISA Kits) signals in a lineage-specific fashion
WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling.
these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt (show WNT2 ELISA Kits) ligands.
regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt (show WNT2 ELISA Kits) signaling
Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.
Wls-mediated secretion of Wnt (show WNT2 ELISA Kits) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.
eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (show WNT2 ELISA Kits) activity, leading to inhibition of odontoblast maturation and root elongation.
The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (show ATOH1 ELISA Kits), and Pax6 (show PAX6 ELISA Kits) in the rhombic lip provides novel views of early cerebellar development.
Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium
The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt (show WNT2 ELISA Kits) proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development.
Gpr177 regulates pulmonary vasculature development.
Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.
The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (show WNT2 ELISA Kits) secretion in a variety of embryonic and adult tissue types.
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
G protein-coupled receptor 177
, integral membrane protein GPR177
, protein evenness interrupted homolog
, protein wntless homolog
, putative NF-kappa-B-activating protein 373
, putative NFkB activating protein 373