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Wntless Homolog (Drosophila) Proteins (WLS)

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Additionally we are shipping WLS Antibodies (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WLS 79971 Q5T9L3
Mouse WLS WLS 68151 Q6DID7
Rat WLS WLS 362065 Q6P689
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Top WLS Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$382.86
Details

WLS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced WLS Proteins

  1. Human WLS Protein expressed in Escherichia coli (E. coli) - ABIN1098794 : Ji, Grossmann, Ji: G protein-coupled receptors. I. Diversity of receptor-ligand interactions. in The Journal of biological chemistry 1998 (PubMed)

More Proteins for Wntless Homolog (Drosophila) (WLS) Interaction Partners

Human Wntless Homolog (Drosophila) (WLS) interaction partners

  1. Genetic variation at the WLS and CCDC170 (show CCDC170 Proteins)/ESR1 (show ESR1 Proteins) loci were found to be significantly associated with bone mineral density

  2. This study has revealed a strong association between the expression of WLS and HER2 (show ERBB2 Proteins) that has important biological and clinical implications.

  3. This study identified CMTM8 (show CMTM8 Proteins) as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene (show RAB1A Proteins) in osteosarcoma.

  4. GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia.

  5. endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi.

  6. Colorectal tumors express elevated levels of Wnt3 and GPR177.

  7. The data suggest that the common variants of WLS analyzed in this study are not associated with opioid or cocaine addiction.

  8. Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.

  9. findings lead to a proposed mechanism by which Gpr177 controls skeletal development through modulation of autocrine and paracrine Wnt (show WNT2 Proteins) signals in a lineage-specific fashion

  10. WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling.

Mouse (Murine) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt (show WNT2 Proteins) ligands.

  2. regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt (show WNT2 Proteins) signaling

  3. Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.

  4. Wls-mediated secretion of Wnt (show WNT2 Proteins) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.

  5. eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (show WNT2 Proteins) activity, leading to inhibition of odontoblast maturation and root elongation.

  6. The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (show ATOH1 Proteins), and Pax6 (show PAX6 Proteins) in the rhombic lip provides novel views of early cerebellar development.

  7. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

  8. The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt (show WNT2 Proteins) proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development.

  9. Gpr177 regulates pulmonary vasculature development.

  10. Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.

Zebrafish Wntless Homolog (Drosophila) (WLS) interaction partners

  1. Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.

  2. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (show WNT2 Proteins) secretion in a variety of embryonic and adult tissue types.

WLS Protein Profile

Protein Summary

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene names and symbols associated with WLS

  • wntless homolog (Drosophila) (WLS)
  • wntless homolog (Drosophila) (Wls)
  • wntless homolog (Drosophila) (wls)
  • 5031439A09Rik protein
  • AI173978 protein
  • AI987742 protein
  • C1orf139 protein
  • EVI protein
  • gpr117 protein
  • gpr177 protein
  • mig-14 protein
  • MRP protein
  • sb:cb610 protein
  • wu:fb36d04 protein
  • wu:fb44d10 protein
  • wu:fb50c06 protein
  • zgc:64091 protein

Protein level used designations for WLS

G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , EVI

GENE ID SPECIES
79971 Homo sapiens
611491 Canis lupus familiaris
528123 Bos taurus
68151 Mus musculus
362065 Rattus norvegicus
406420 Danio rerio
424707 Gallus gallus
Selected quality suppliers for WLS Proteins (WLS)
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