Wntless Homolog (Drosophila) Proteins (WLS)

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Additionally we are shipping WLS Antibodies (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WLS 79971 Q5T9L3
Mouse WLS WLS 68151 Q6DID7
Rat WLS WLS 362065 Q6P689
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Top WLS Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days

WLS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Wntless Homolog (Drosophila) (WLS) Interaction Partners

Human Wntless Homolog (Drosophila) (WLS) interaction partners

  1. we identified novel associations in WLS , ARHGAP1 (show ARHGAP1 Proteins) , and 5' of MEF2C (show MEF2C Proteins) ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD (show BEST1 Proteins) compared to the GWAS SNPs.

  2. Our data suggest that Wls protein is related to tumor metastasis and advanced TNM (show ODZ1 Proteins) stage, and may be used as a new marker for prognosis of gastric carcinoma.

  3. These results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma.

  4. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  5. Genetic variation at the WLS and CCDC170 (show CCDC170 Proteins)/ESR1 (show ESR1 Proteins) loci were found to be significantly associated with bone mineral density

  6. This study has revealed a strong association between the expression of WLS and HER2 (show ERBB2 Proteins) that has important biological and clinical implications.

  7. This study identified CMTM8 (show CMTM8 Proteins) as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene (show RAB1A Proteins) in osteosarcoma.

  8. GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia.

  9. endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi.

  10. Colorectal tumors express elevated levels of Wnt3 and GPR177.

Mouse (Murine) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner.

  2. these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt (show WNT2 Proteins) ligands.

  3. regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt (show WNT2 Proteins) signaling

  4. Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.

  5. Wls-mediated secretion of Wnt (show WNT2 Proteins) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.

  6. eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (show WNT2 Proteins) activity, leading to inhibition of odontoblast maturation and root elongation.

  7. The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (show ATOH1 Proteins), and Pax6 (show PAX6 Proteins) in the rhombic lip provides novel views of early cerebellar development.

  8. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

  9. The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt (show WNT2 Proteins) proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development.

  10. Gpr177 regulates pulmonary vasculature development.

Zebrafish Wntless Homolog (Drosophila) (WLS) interaction partners

  1. the chaperon Wls and its ligands Wnt9a (show WNT9A Proteins) and Wnt5b (show WNT5B Proteins) are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (show FRZB Proteins) and Gpc4 (show GPC4 Proteins).

  2. disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4 (show GPC4 Proteins), wnt5b (show WNT5B Proteins) and wnt9a (show WNT9A Proteins) resulted in severely delayed endochondral ossification.

  3. Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.

  4. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (show WNT2 Proteins) secretion in a variety of embryonic and adult tissue types.

Fruit Fly (Drosophila melanogaster) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  2. The uncharacterized Drosophila protein Evi5 was identified as an essential membrane trafficking regulator, and the molecular mechanism by which Evi5 regulates BC migration was described.

  3. Syx1A, Rab11, and its effector Myosin5 were required for proper Evi vesicle release.

  4. DSNX3 regulates Wg secretion via retromer-dependent Wls recycling

  5. Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.

  6. we propose that Wntless represents an ancient partner for Wnts dedicated to promoting their secretion into the extracellular milieu.

  7. The function of Srt is restricted to events occurring within the Wg-producing cells, study shows that srt is not required for any aspect of Hedgehog (Hh) signal transduction, suggesting specificity of srt for the Wg pathway.

  8. Recent studies have identified Wntless (Wls) and the retromer complex as essential components involved in Wnt signaling.

  9. Wg, clathrin-mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling Wls to direct Wnt (show WNT4 Proteins) secretion.

  10. WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity

WLS Protein Profile

Protein Summary

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene names and symbols associated with WLS

  • wntless homolog (Drosophila) (WLS)
  • wntless homolog (Drosophila) (Wls)
  • wntless homolog (Drosophila) (wls)
  • wntless (wls)
  • 5031439A09Rik protein
  • AI173978 protein
  • AI987742 protein
  • C1orf139 protein
  • CG6210 protein
  • Dmel\\CG6210 protein
  • evi protein
  • Evi/Wls protein
  • gpr117 protein
  • gpr177 protein
  • mig-14 protein
  • MRP protein
  • sb:cb610 protein
  • srt protein
  • Wls protein
  • wls/evi protein
  • wu:fb36d04 protein
  • wu:fb44d10 protein
  • wu:fb50c06 protein
  • zgc:64091 protein

Protein level used designations for WLS

G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , EVI , CG6210-PA , CG6210-PB , evenness interrupted , sprinter , wls-PA , wls-PB

79971 Homo sapiens
68151 Mus musculus
362065 Rattus norvegicus
406420 Danio rerio
424707 Gallus gallus
528123 Bos taurus
39259 Drosophila melanogaster
611491 Canis lupus familiaris
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