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Wolf-Hirschhorn Syndrome Candidate 1-Like 1 Proteins (WHSC1L1)

WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. Additionally we are shipping WHSC1L1 Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat WHSC1L1 WHSC1L1 290831  
WHSC1L1 54904 Q9BZ95
WHSC1L1 234135 Q6P2L6
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Top WHSC1L1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human GST tag Recombinant WHSC1L1 / NSD3 - SET activity using AlphaLISA. WHSC1L1 / NSD3 - SET was used in an AlphaLISA assay to determine enzyme linearity. This data was generated and kindly provided courtesy of ChemPartner. Recombinant WHSC1L1 / NSD3 - SET protein gel. Recombinant WHSC1L1 / NSD3 - SET run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
$460.83
Details

WHSC1L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1) Interaction Partners

Human Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1) interaction partners

  1. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET (show WHSC1 Proteins) and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  2. Results demonstrate that the AML maintenance function of BRD4 requires its interaction with the short isoform of NSD3 lacking the methyltransferase domain. This protein is an adaptor that sustains leukemia by linking BRD4 to the CHD8 chromatin remodeler.

  3. The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.

  4. The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target.

  5. PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines.

  6. Data indicate that siRNA attenuated the expression levels of CCNG1 (show CCNG1 Proteins) and NEK7 (show NEK7 Proteins), implying that WHSC1L1 appears to activate the expression of CCNG1 (show CCNG1 Proteins) and NEK7 (show NEK7 Proteins) in cancer cells.

  7. methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 (show HIST3H3 Proteins) recognition

  8. Functional studies with Brd4 (show BRD4 Proteins) indicate that the ET domain mediates pTEFb (show CDK9 Proteins)-independent transcriptional activation through a subset of these associated factors, including NSD3.

  9. Overexpression of WHSC1L1 gene is associated with breast cancer.

WHSC1L1 Protein Profile

Protein Summary

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.

Gene names and symbols associated with WHSC1L1

  • Wolf-Hirschhorn syndrome candidate 1-like 1 (Whsc1l1)
  • Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1)
  • Wolf-Hirschhorn syndrome candidate 1-like 1 (whsc1l1)
  • Wolf-Hirschhorn syndrome candidate 1-like 1 (LOC100228404)
  • Wolf-Hirschhorn syndrome candidate 1-like 1 (human) (Whsc1l1)
  • 6720429E03 protein
  • A530023P05 protein
  • AI528490 protein
  • NSD3 protein
  • pp14328 protein
  • WHISTLE protein
  • WHSC1L1 protein

Protein level used designations for WHSC1L1

histone-lysine N-methyltransferase NSD3 , Wolf-Hirschhorn syndrome candidate 1-like 1 , histone-lysine N-methyltransferase NSD3-like , WHSC1-like 1 isoform 9 with methyltransferase activity to lysine , WHSC1-like protein 1 , nuclear SET domain-containing protein 3 , protein whistle , wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog

GENE ID SPECIES
290831 Rattus norvegicus
426778 Gallus gallus
464119 Pan troglodytes
475584 Canis lupus familiaris
700254 Macaca mulatta
100006350 Danio rerio
100029834 Monodelphis domestica
100057692 Equus caballus
100074284 Ornithorhynchus anatinus
100216035 Xenopus (Silurana) tropicalis
100228404 Taeniopygia guttata
100352710 Oryctolagus cuniculus
100389349 Callithrix jacchus
100459660 Pongo abelii
100550821 Meleagris gallopavo
100558428 Anolis carolinensis
100599595 Nomascus leucogenys
54904 Homo sapiens
234135 Mus musculus
Selected quality suppliers for WHSC1L1 Proteins (WHSC1L1)
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