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anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) Antibodies

WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. Additionally we are shipping Wolf-Hirschhorn Syndrome Candidate 2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WHSC2 305455  
WHSC2 7469 Q9H3P2
WHSC2 24116 Q8BG30
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Top anti-Wolf-Hirschhorn Syndrome Candidate 2 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB WHSC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the WHSC2 antibody detected the WHSC2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated WB WHSC2 Antibody (Center) (ABIN658722) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the WHSC2 antibody detected the WHSC2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of WHSC2 expression in transfected 293T cell line by WHSC2 MaxPab polyclonal antibody.Lane 1: WHSC2 transfected lysate(58.08 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to WHSC2 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ICC, FACS, IHC (p), ELISA, WB   50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Chicken Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$463.83
Details

WHSC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)
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,
Human , ,
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Mouse (Murine)


Top referenced anti-Wolf-Hirschhorn Syndrome Candidate 2 Antibodies

  1. Human Monoclonal WHSC2 Primary Antibody for ICC, FACS - ABIN1724801 : Yung, Narita, Komori, Yamaguchi, Handa: Cellular dynamics of the negative transcription elongation factor NELF. in Experimental cell research 2009 (PubMed)
    Show all 2 references for ABIN1724801

  2. Human Monoclonal WHSC2 Primary Antibody for ICC, FACS - ABIN1724802 : Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome. in Human molecular genetics 2012 (PubMed)
    Show all 2 references for ABIN1724802

  3. Human Polyclonal WHSC2 Primary Antibody for EIA, WB - ABIN953645 : Hanna, Kruskal, Ezekowitz, Bloom, Collier: Role of macrophage oxidative burst in the action of anthrax lethal toxin. in Molecular medicine (Cambridge, Mass.) 1996 (PubMed)

  4. Human Polyclonal WHSC2 Primary Antibody for WB - ABIN658722 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against Wolf-Hirschhorn Syndrome Candidate 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) interaction partners

  1. The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E (show RDBP Antibodies) show that these phenotypes result from the reduced activity of the NELF (show RDBP Antibodies) complex.

  2. analysis of the interactions between DSIF (show SUPT4H1 Antibodies) (DRB sensitivity inducing factor), NELF (negative elongation factor (show RDBP Antibodies)), and the Drosophila RNA polymerase II transcription elongation complex

Human Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) interaction partners

  1. These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A and NELF-B (show COBRA1 Antibodies), relative to other factors in the overall gene induction sequence.

  2. data show that NELF (show NELF Antibodies) subunits exhibit highly specific subcellular localizations, such as in NELF (show NELF Antibodies) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (show NELF Antibodies) from cells can lead to enlarged and/or multiple nuclei

  3. haploinsufficiency of SLBP (show SLBP Antibodies) and/or WHSC2 (NELF-A) contributes to several novel cellular phenotypes of WHS (show WHSC1 Antibodies).

  4. NELF-C (show TH1L Antibodies) and NELF-D (show TH1L Antibodies) are highly related or identical to the protein called TH1 (show TH1L Antibodies), of unknown function. NELF-B (show COBRA1 Antibodies) and NELF-C (show TH1L Antibodies) or NELF-D (show TH1L Antibodies) are integral subunits that bring NELF-A and NELF-E (show RDBP Antibodies) together. [NELF-B (show COBRA1 Antibodies)] [NELF-C (show TH1L Antibodies)]

  5. connection between the syndrome phenotype and cytogenetic abnormalities, through gradual shortening of the length of the critical region WHSCR (finally up to 165 kb), and sequencing it, at least 2 genes (WHSC1 (show WHSC1 Antibodies) and WHSC2) were identified.

  6. Negative elongation factor (NELF (show RDBP Antibodies)) is a four subunit transcription factor. Our results point to a surprising role of NELF (show NELF Antibodies) in the 3' end processing of histone mRNAs and suggest that NELF (show NELF Antibodies) is a new factor that coordinates mRNA processing in transcription

Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) Antigen Profile

Protein Summary

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Gene names and symbols associated with WHSC2

  • Negative elongation factor A (Nelf-A) antibody
  • negative elongation factor complex member A (Nelfa) antibody
  • negative elongation factor complex member A (nelfa) antibody
  • Wolf-Hirschhorn syndrome candidate 2 (whsc2) antibody
  • Wolf-Hirschhorn syndrome candidate 2 (WHSC2) antibody
  • negative elongation factor complex member A (NELFA) antibody
  • negative elongation factor complex member A, Whsc2 (Nelfa) antibody
  • BcDNA:SD07139 antibody
  • CG5874 antibody
  • Dmel\\CG5874 antibody
  • fi75f03 antibody
  • MGC85474 antibody
  • NELF antibody
  • nelf-a antibody
  • nelfa antibody
  • p/okcl.15 antibody
  • WHSC2 antibody
  • Whsc2h antibody
  • wu:fi75f03 antibody

Protein level used designations for WHSC2

CG5874-PA , CG5874-PB , NELF-A , Nelf-A-PA , Nelf-A-PB , negative elongation factor A , Wolf-Hirschhorn syndrome candidate 2 protein , Wolf-Hirschhorn syndrome candidate 2 , negative elongation factor A-like , wolf-Hirschhorn syndrome candidate 2 protein , Wolf-Hirschhorn syndrome candidate 2 homolog , mWHSC2

GENE ID SPECIES
42520 Drosophila melanogaster
305455 Rattus norvegicus
559677 Danio rerio
447614 Xenopus laevis
461071 Pan troglodytes
488806 Canis lupus familiaris
100022673 Monodelphis domestica
100135733 Xenopus (Silurana) tropicalis
100434253 Pongo abelii
100514855 Sus scrofa
100543149 Meleagris gallopavo
7469 Homo sapiens
24116 Mus musculus
Selected quality suppliers for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) Antibodies
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