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Wolf-Hirschhorn Syndrome Candidate 2 Proteins (WHSC2)

WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. Additionally we are shipping Wolf-Hirschhorn Syndrome Candidate 2 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat WHSC2 WHSC2 305455  
WHSC2 7469 Q9H3P2
Mouse WHSC2 WHSC2 24116 Q8BG30
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Top Wolf-Hirschhorn Syndrome Candidate 2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

WHSC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced Wolf-Hirschhorn Syndrome Candidate 2 Proteins

  1. Human WHSC2 Protein expressed in Escherichia coli (E. coli) - ABIN667859 : Carè, Catalucci, Felicetti, Bonci, Addario, Gallo, Bang, Segnalini, Gu, Dalton, Elia, Latronico, Høydal, Autore, Russo, Dorn, Ellingsen, Ruiz-Lozano, Peterson, Croce, Peschle, Condorelli: MicroRNA-133 controls cardiac hypertrophy. in Nature medicine 2007 (PubMed)
    Show all 2 references for ABIN667859

More Proteins for Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) interaction partners

  1. The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E (show RDBP Proteins) show that these phenotypes result from the reduced activity of the NELF (show RDBP Proteins) complex.

  2. analysis of the interactions between DSIF (show SUPT4H1 Proteins) (DRB sensitivity inducing factor), NELF (negative elongation factor (show RDBP Proteins)), and the Drosophila RNA polymerase II transcription elongation complex

Human Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) interaction partners

  1. These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A and NELF-B (show COBRA1 Proteins), relative to other factors in the overall gene induction sequence.

  2. data show that NELF (show NELF Proteins) subunits exhibit highly specific subcellular localizations, such as in NELF (show NELF Proteins) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (show NELF Proteins) from cells can lead to enlarged and/or multiple nuclei

  3. haploinsufficiency of SLBP (show SLBP Proteins) and/or WHSC2 (NELF-A) contributes to several novel cellular phenotypes of WHS (show WHSC1 Proteins).

  4. NELF-C (show TH1L Proteins) and NELF-D (show TH1L Proteins) are highly related or identical to the protein called TH1 (show TH1L Proteins), of unknown function. NELF-B (show COBRA1 Proteins) and NELF-C (show TH1L Proteins) or NELF-D (show TH1L Proteins) are integral subunits that bring NELF-A and NELF-E (show RDBP Proteins) together. [NELF-B (show COBRA1 Proteins)] [NELF-C (show TH1L Proteins)]

  5. connection between the syndrome phenotype and cytogenetic abnormalities, through gradual shortening of the length of the critical region WHSCR (finally up to 165 kb), and sequencing it, at least 2 genes (WHSC1 (show WHSC1 Proteins) and WHSC2) were identified.

  6. Negative elongation factor (NELF (show RDBP Proteins)) is a four subunit transcription factor. Our results point to a surprising role of NELF (show NELF Proteins) in the 3' end processing of histone mRNAs and suggest that NELF (show NELF Proteins) is a new factor that coordinates mRNA processing in transcription

Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) Protein Profile

Protein Summary

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Gene names and symbols associated with WHSC2

  • Negative elongation factor A (Nelf-A)
  • negative elongation factor complex member A (Nelfa)
  • negative elongation factor complex member A (nelfa)
  • Wolf-Hirschhorn syndrome candidate 2 (whsc2)
  • Wolf-Hirschhorn syndrome candidate 2 (WHSC2)
  • negative elongation factor complex member A (NELFA)
  • negative elongation factor complex member A, Whsc2 (Nelfa)
  • BcDNA:SD07139 protein
  • CG5874 protein
  • Dmel\\CG5874 protein
  • fi75f03 protein
  • MGC85474 protein
  • NELF protein
  • nelf-a protein
  • nelfa protein
  • p/okcl.15 protein
  • WHSC2 protein
  • Whsc2h protein
  • wu:fi75f03 protein

Protein level used designations for WHSC2

CG5874-PA , CG5874-PB , NELF-A , Nelf-A-PA , Nelf-A-PB , negative elongation factor A , Wolf-Hirschhorn syndrome candidate 2 protein , Wolf-Hirschhorn syndrome candidate 2 , negative elongation factor A-like , wolf-Hirschhorn syndrome candidate 2 protein , Wolf-Hirschhorn syndrome candidate 2 homolog , mWHSC2

GENE ID SPECIES
42520 Drosophila melanogaster
305455 Rattus norvegicus
559677 Danio rerio
447614 Xenopus laevis
461071 Pan troglodytes
488806 Canis lupus familiaris
100022673 Monodelphis domestica
100135733 Xenopus (Silurana) tropicalis
100434253 Pongo abelii
100514855 Sus scrofa
100543149 Meleagris gallopavo
7469 Homo sapiens
24116 Mus musculus
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