anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Antibodies

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WHSC1 7468 O96028
WHSC1 680537  
WHSC1 107823 Q8BVE8
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Top anti-WHSC1 Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-WHSC1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ChIPSeq, ChIP, ICC, IF, WB MMSET / WHSC1 antibody (mAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with chromatin from a human multiple myeloma cell line (4.5 million cells) and 10 µl of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 23 million sequence tags were mapped to identify MMSET binding patterns. The panel on the left shows binding across 12 million bp on chromosome 12. The panel on the right is zoomed in to show individual peaks. MMSET / WHSC1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with MMSET / WHSC1 antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$507.50
Details
Chicken Rabbit Un-conjugated IHC (p), WB Anti-WHSC1 / NSD2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1105042 dilution 38474 ug/ml. 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated WB WHSC1 Antibody (C-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the WHSC1 antibody detected the WHSC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using NSD2, antibody at 1:100 dilution. WB Image Sample(30 ug whole cell lysate) A:Raji , 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of WHSC1 expression in transfected 293T cell line by WHSC1 MaxPab polyclonal antibody.<br><br>Lane1:WHSC1 transfected lysate(71.17 KDa).<br>Lane2:Non-transfected lysate.<br> Immunofluorescence of <u>purified</u> MaxPab antibody to WHSC1 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p)   0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: WHSC1 Antibody [NBP1-30910] - Sample(30 ug whole cell lysate)A:Raji (GTX27908)5% SDS PAGE, antibody diluted at 1:1000. Immunohistochemistry-Paraffin: WHSC1 Antibody [NBP1-30910] - Paraffin-embedded A549 xenograft, using antibody at 1:100 dilution. 100 μL Log in to see 7 to 9 Days
$447.56
Details
Chicken Rabbit Un-conjugated WB   50 μg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

WHSC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Rat (Rattus)


Mouse (Murine)


Top referenced anti-WHSC1 Antibodies

  1. Human Polyclonal WHSC1 Primary Antibody for ICC, IF - ABIN4366102 : Toyokawa, Cho, Masuda, Yamane, Yoshimatsu, Hayami, Takawa, Iwai, Daigo, Tsuchiya, Tsunoda, Field, Kelly, Neal, Maehara, Ponder, Nakamura, Hamamoto: Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. in Neoplasia (New York, N.Y.) 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal WHSC1 Primary Antibody for ChIPSeq, ChIP - ABIN2668917 : Marango, Shimoyama, Nishio, Meyer, Min, Sirulnik, Martinez-Martinez, Chesi, Bergsagel, Zhou, Waxman, Leibovitch, Walsh, Licht: The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. in Blood 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal WHSC1 Primary Antibody for IF, WB - ABIN521379 : Huang, Wu, Chuai, Xu, Yan, Englund, Wang, Zhang, Fang, Wang, Gu, Zhang, Yang, Zhao, Yu, Dai, Yi, Zhou, Li, Wu, Liu, Wu, Chan, Lu, Atadja, Li, Wang, Hu: NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma. in Cancer research 2013 (PubMed)

  4. Dog (Canine) Polyclonal WHSC1 Primary Antibody for WB - ABIN2777965 : Santra, Zhan, Tian, Barlogie, Shaughnessy: A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. in Blood 2003 (PubMed)
    Show all 2 Pubmed References

More Antibodies against WHSC1 Interaction Partners

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. These findings indicate that the miR (show MLXIP Antibodies)-2392-MAML3 (show MAML3 Antibodies)/WHSC1-Slug (show SNAI2 Antibodies)/Twist1 (show TWIST1 Antibodies) regulatory axis plays a critical role in GC metastasis.

  2. In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.

  3. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  4. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

  5. Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.

  6. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.

  7. In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.

  8. results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.

  9. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation

  10. Studies indicate that the NSD methyltransferases NSD1 (show NSD1 Antibodies), NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (show WHSC1L1 Antibodies) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) interaction partners

  1. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  2. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  3. Histone H3 (show HIST3H3 Antibodies) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (show RUNX2 Antibodies) and p300 (show NOTCH1 Antibodies) in the activation of bone-related genes

  4. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Antibodies), HYPB (show SETD2 Antibodies), NSD1 (show NSD1 Antibodies), and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Antibodies), and Pr-Set7 (show SETD8 Antibodies) were not affected by ubH2A.

  5. WHSC1 links transcription elongation to HIRA (show HIRA Antibodies)-mediated histone H3.3 (show H3F3A Antibodies) deposition.

  6. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Antigen Profile

Protein Summary

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Gene names and symbols associated with WHSC1

  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1) antibody
  • Wolf-Hirschhorn syndrome candidate 1 (whsc1) antibody
  • Wolf-Hirschhorn syndrome candidate 1 (Whsc1) antibody
  • Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1) antibody
  • 5830445G22Rik antibody
  • 9430010A17Rik antibody
  • AW555663 antibody
  • C130020C13Rik antibody
  • D030027O06Rik antibody
  • D930023B08Rik antibody
  • fc12c04 antibody
  • mKIAA1090 antibody
  • MMSET antibody
  • NSD2 antibody
  • REIIBP antibody
  • RGD1565590 antibody
  • si:rp71-77d7.2 antibody
  • TRX5 antibody
  • WHS antibody
  • WHSC1 antibody
  • Whsc1l antibody
  • wu:fc12c04 antibody
  • wu:fi20c01 antibody

Protein level used designations for WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

GENE ID SPECIES
461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
Selected quality suppliers for anti-WHSC1 (WHSC1) Antibodies
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