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WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Proteins (5) and many more products for this protein.
Showing 10 out of 43 products:
Human Polyclonal WHSC1 Primary Antibody for ICC, IF - ABIN4366102
Toyokawa, Cho, Masuda, Yamane, Yoshimatsu, Hayami, Takawa, Iwai, Daigo, Tsuchiya, Tsunoda, Field, Kelly, Neal, Maehara, Ponder, Nakamura, Hamamoto: Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. in Neoplasia (New York, N.Y.) 2011
Show all 3 Pubmed References
Human Monoclonal WHSC1 Primary Antibody for ChIPSeq, ChIP - ABIN2668917
Marango, Shimoyama, Nishio, Meyer, Min, Sirulnik, Martinez-Martinez, Chesi, Bergsagel, Zhou, Waxman, Leibovitch, Walsh, Licht: The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. in Blood 2008
Show all 2 Pubmed References
Human Polyclonal WHSC1 Primary Antibody for IF, WB - ABIN521379
Huang, Wu, Chuai, Xu, Yan, Englund, Wang, Zhang, Fang, Wang, Gu, Zhang, Yang, Zhao, Yu, Dai, Yi, Zhou, Li, Wu, Liu, Wu, Chan, Lu, Atadja, Li, Wang, Hu: NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma. in Cancer research 2013
Dog (Canine) Polyclonal WHSC1 Primary Antibody for WB - ABIN2777965
Santra, Zhan, Tian, Barlogie, Shaughnessy: A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. in Blood 2003
Show all 2 Pubmed References
These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.
These findings indicate that the miR (show MLXIP Antibodies)-2392-MAML3 (show MAML3 Antibodies)/WHSC1-Slug (show SNAI2 Antibodies)/Twist1 (show TWIST1 Antibodies) regulatory axis plays a critical role in GC metastasis.
In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.
data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer
NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.
Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.
Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.
In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.
results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.
NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation
Studies indicate that the NSD methyltransferases NSD1 (show NSD1 Antibodies), NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (show WHSC1L1 Antibodies) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.
WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies
Histone H3 (show HIST3H3 Antibodies) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (show RUNX2 Antibodies) and p300 (show NOTCH1 Antibodies) in the activation of bone-related genes
all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Antibodies), HYPB (show SETD2 Antibodies), NSD1 (show NSD1 Antibodies), and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Antibodies), and Pr-Set7 (show SETD8 Antibodies) were not affected by ubH2A.
WHSC1 links transcription elongation to HIRA (show HIRA Antibodies)-mediated histone H3.3 (show H3F3A Antibodies) deposition.
H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Wolf-Hirschhorn syndrome candidate 1 protein
, Wolf-Hirschhorn syndrome candidate 1
, probable histone-lysine N-methyltransferase NSD2
, IL5 promoter REII region-binding protein
, histone-lysine N-methyltransferase NSD2
, multiple myeloma SET domain containing protein type III
, nuclear SET domain-containing protein 2
, trithorax/ash1-related protein 5
, multiple myeloma SET domain-containing protein
, wolf-Hirschhorn syndrome candidate 1 protein homolog